I.V. CHERNOKHAEVA¹, М.V. PAVLOVA¹, А.А. STARSHINOVA¹, E.N. BELYAEVA¹, N.V. SAPOZHNIKOVA¹, P.V. GAVRILOV¹, V.Yu. ZHURAVLEV¹, L.I. ARCHAKOVA^1,2, P.K. YABLONSKIY^1,2

¹St. Petersburg Scientific and Research Institute of Phthisiopulmonology of the MH of RF, 2-4 Ligovskiy Ave., St. Petersburg, Russian Federation, 191036

²St.Petersburg State University, 8 line 21, V. I., St. Petersburg, Russian Federation, 199034

Chernokhaeva I.V. — junior researcher of the Department of pulmonary tuberculosis therapy, tel. (812) 579-25-06, e-mail: spbniif_all@mail.ru

Pavlova M.V. — D. Med. Sc., Professor, Head of the Department of pulmonary tuberculosis therapy, tel. (812) 579-25-06, e-mail: mv@spbniif.ru

Starshinova A.A. — D. Med. Sc., Head of the Department of Phthisiopulmonology, tel. (812) 579-25-06, e-mail: starshinova_777@mail.ru

Belyaeva E.N. — junior researcher, tel. (812) 579-25-06, e-mail: spbniif_all@mail.ru

Sapozhnikova N.V. — Cand. Med. Sc., Senior Researcher of the Department of pulmonary tuberculosis therapy, tel. (812) 579-25-06, e-mail: spbniif_all@mail.ru

Gavrilov P.V. — Cand. Med. Sc., Head of the Department of Radiation Diagnosis, tel. (812) 579-25-06, e-mail: spbniif_all@mail.ru

Zhuravlev V.Yu. — Cand. Med. Sc., Head of the Department laboratory diagnostics, tel. (812) 579-25-06, e-mail: spbniif_all@mail.ru

Archakova L.I. — D. Med. Sc., Head of the Department of pulmonary tuberculosis therapy, tel. (812) 579-25-06, e-mail: spbniif_all@mail.ru

Yablonskiy P.K. — D. Med. Sc., Professor, Head of St. Petersburg Scientific and Research Institute of Phthisiopulmonology of the MH of RF, tel. (812) 579-25-06, e-mail: glhirurgb2@mail.ru

Within recent years in Russian Federation stabilization of the epidemic process of tuberculosis is observing. However, this situation is not sustainable, due to the increasing prevalence of multidrug resistance (MDR) Mycobacterium tuberculosis (MBT). During the period from 2002 to 2012 in Russian Federation proportion of patients with MDR MBT among all newly diagnosed patients with respiratory tuberculosis with bacterial excretion was doubled. Currently the effectiveness of therapy in patients with MDR worldwide and in Russian Federation does not exceed 48.7%. Treatment of multidrug-resistant (MDR) is a difficult task. Since 2013 in Russian Federation upon registration of perсhlozon and its application in routine clinical practice for treatment of multidrug-resistant pathogen opportunities for its further efficacy and safety appeared. Use of the drug perсhlozon in complex therapy of pulmonary tuberculosis caused by multidrug-resistant pathogen significantly increased the effectiveness of 6 months therapy evaluated by basic criteria — cassation of bacterial excretion and positive radiological dynamics.

Key words: tuberculosis, antituberculous treatment, Perchlozon.

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