K.A. VOROBYOV, S.A. BOZHKOVA, L.I. ANISIMOVA, G.I. NETYLKO

Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. Vreden of the Ministry of Health of the Russian Federation, Saint Petersburg

  Сontact details:

Vorobyov K.A. – Researcher at the Surgical Department for Coordination of Donation of Human Organs and/or Tissues

Address: 8 Akademika Baykova St., Saint Petersburg, Russian Federation 195427, Russian Federation, e-mail: vorobyov_doc@mail.ru

Two groups of bone-replacement materials based on the cancellous bone and processed by two different methods were studied. The in vivo experiment was performed on 24 rabbits of the Chinchilla breed with a formed cavity defect, replaced by the test materials, 12 animals per group: the experimental group (n=12) and the control group (n=12). Histomorphological studies were performed in both groups at the 7, 21, 45, and 90^th days of observation, staining was performed with hematoxylin and eosin, and Mallory method. It is revealed that the methods of processing and sterilization used in the manufacture of bone-substituting material, change its osteoconductive and osteoinductive characteristics, affect the processes of resorption, osteointegration and remodeling after implantation during reconstructive plastic interventions on the skeletal bone tissues.

Key words: bone defect, bone substituting materials, osteoinduction, osteoconduction, osteointegration, remodeling.

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