S.D. MAYANSKAYA¹, M.M. MANGUSHEVA¹, A.A. GILMANOV², O.YU. MIHOPAROVA³, O.B. OSHEPKOVA³, G.A. FADEEV³

 ¹Kazan State Medical University, Кazan

²Republican Clinical Hospital, Kazan

³Medical unit of the Ministry of Internal Affairs of RT, Kazan

 Contact details:

Маyanskaya S.D. — MD, Professor, Department of Hospital Therapy

Address: 36 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7-905-316-99-66, e-mail: Smayanskaya@mail.ru

 The article presents a description of a clinical case of the appearance of characteristic ECG signs of Brugada syndrome type 1 in the form of incomplete blockade of the right bundle branch block, «convex» ST elevation of 2 mm and negative symmetrical T-wave inversion in V1-V2 in a practically healthy patient after a new coronavirus infection (COVID-19). On the control ECG performed a week later, these signs reduced to a latent form. However, there is an assumption that the Brugada syndrome in a woman had existed in a latent form, and against the background of COVID-19, it transformed into its active variant. Unfortunately, we do not have data on how long these signs were present on the ECG, as the ECG was recorded a week after COVID-19. The clinical case we demonstrate shows a possible relationship between the transient nature of type 1 Brugada syndrome and COVID-19, which requires further study.

The article also provides examples of other clinical cases of the appearance of signs of Brugada syndrome on the ECG in patients with COVID-19 according to various literature data.

Key words: Brugada syndrome, COVID-19, Brugada syndrome signs on ECG.

REFERENCES

1. Brugada R., Campuzano O., Sarquella-Brugada G., et al. Brugada syndrome. Methodist Debakey. Cardiovasc J, 2014, vol. 10, pp. 25–28.
2. Mayanskaya S.D., Tsibul’kin N.A. Brugada Syndrome. Prakticheskaya meditsina, 2015, no. 3-2 (88), pp. 25–30 (in Russ.).
3. Chang D., Saleh M., Garcia-Bengo Y. et al. Infection Unmasking Brugada Syndrome. Heart Rhythm Case Reports, 2020, vol 6 (5), pp. 237–240.
4. Bayés De Luna A., Brugada J., Baranchuk A., et al. Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus report. J Electrocardiol, 2012, vol. 45, pp. 433–442.
5. Chawla S., Afzal S., Lak H.M. et al. SARS-COV2 (COVID-19) Unmasking Brugada Pattern. JACC, 2021, vol. 77 (18), p. 2950.
6. Dommaraju S., Avula S., Buch T. et al. Brugada pattern unmasked by COVID-19 infection complicated by cardiogenic shock. JACC, 2021, vol. 77 (18), p. 2020.
7. Yang Z., Prinsen J.K., Bersell K.R. et al. Azithromycin causes a novel proarrhythmic syndrome. Circ Arrhythm Electrophysiol., 2017, no.10, e003560.
8. Tsimploulis A., Rashba F.J., Rahman T. et al. Medication unmasked Brugada syndrome and cardiac arrest in a COVID-19 patient. FHRS Heart Rhythm Case Reports, 2020, vol. 6 (9), pp. 554–557.