N.A. BOGDANOVA¹, V.I. KIRILLOV¹, S.L. MOROZOV³, S.Yu. NIKITINA²

¹A.I. Evdokimov Moscow State University of Medicine and Dentistry, 20 Delegatskaya Str., building 1, Moscow, Russian Federation, 127473

²Saint Vladimir Children’s City Hospital, 1/3 Rubtsovsko-Dvortsovaya Str., Moscow, Russian Federation, 107014

³Moscow Research Clinical Institute of Pediatrics named after Acad. Yu.E. Veltishchev of Pirogov Russian National Research Medical University, 2 Taldomskaya Str., Moscow, Russian Federation, 125412

  Bogdanova N.A. ― Cand. Med. Sc., Associate Professor of the Pediatrics Department, e-mail: nataliabogdanova@yandex.ru

The article presents the results of own research to identify the early markers of reflux nephropathy in children. The topic is relevant, as in most cases the untimely or insufficient examination of a child, or asymptomatic course of vesico-ureteric reflux, leads to the emergence of various complications of reflux nephropathy. The study demonstrated that in children with vesicoureteral reflux without nephrosclerosis, there may be functional abnormalities of the proximal tubules, manifested by the decrease of albumin reabsorption. In the early stages of reflux nephropathy, the expressed reduction of low molecular weight proteins reabsorption in the proximal tubules is attached. The development of severe reflux nephropathy is accompanied by total disorders of the nephron various functions, including secretion of this protein in the loop of Henle. Additionally, the study of urine proteinogram enables not only to establish the early signs of renal damage, but also to assess the dynamics of nephrosclerosis development.

Key words: vesicoureteral reflux, reflux nephropathy, urinary proteins, Tamm ― Horsfall protein.

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