D.V. PECHKUROV, V.A. POLKANOVA, E.N. VORONINA, G.YU. PORETSKOVA

Samara State Medical University, Samara

 Contact details:

Pechkurov D.V. — MD, Professor, Head of the Department of Children’s Diseases

Address: 89 Chapayevskaya St., Samara, Russian Federation, 443099, tel.: +7 (846) 959-45-11, e-mail: dmpechkurov@ yandex.ru

The urgency of the problem of searching for sensitive and specific biomarkers of nephron damage in various pathological conditions is due to the increasing prevalence of chronic kidney disease in children. Currently, chronic kidney disease is determined by a decrease in the glomerular filtration rate, however, this indicator is quite variable, and its fluctuations depend on many factors, such as age, features of the disease, nutrition, and physical activity. The article presents an overview of research on the problem of early diagnosis of chronic kidney disease in children. The advantages and disadvantages of early biomarkers of kidney damage are described, which include NGAL, KIM-1, VEGF, TIMP-1, Type IV collagen, serum creatinine, cystatin C. The conducted studies demonstrate the high diagnostic value of cystatin C in the initial stages of chronic kidney disease.

Key words: chronic kidney disease, early diagnosis, preventive nephrology, cystatin C, creatinine, tubular dysfunction, children, NGAL, vascular endothelial growth factor.

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