E.A. DROZDOVA, D.Yu. KHOKHLOVA

South-Ural State Medical University, 64 Vorovskiy Str., Chelyabinsk, Russian Federation, 454092

Drozdova E.A. ― D. Med. Sc., Professor of the Department of Ophthalmology, tel. +7-919-402-92-33, e-mail: dhelena2006@yandex.ru

Khokhlova D.Yu. ― postgraduate student of the Department of Ophthalmology, tel. +7-922-635-89-10, е-mail: xoxlova.d@yandex.ru

The paper presents the results of morphological research of macular edema depending on the concentration of vascular endothelial growth factor (VEGF-A) and interleukin-6 in the serum and tear in patients with RVO after intravitreal introduction (IVI) of ranibizumab. We present the dynamic estimation of structural and immunologic parameters during the macular edema, basing on the carried out spectral optical coherence tomography and enzymatic analysis of blood serum and tear. The obtained data prove that patients with a combination of cystoid macular edema and serous retinal detachment (SRD) had maximum concentration of VEGF-A with a positive correlation dependence of height and extension of SRD. After IVI of ranibizumab, levels of VEGF-A in tear decreased independently on the structural changes in the macula. Thus, the research showed the dependence of morphological parameters of macular edema on the level of cytokines.

Key words: retinal vein occlusion; macular edema; ranibizumab; vascular endothelial growth factor, interleukin-6.

REFERENCES

1. Scholl S., Augustin A., Loewenstein A. General pathophysiology of macular edema. Eur. J. Ophthalmol, 2011, rr. 10-19.
2. Noma H., Funatsu H., Mimura T. Visual function and serous retinal detachment in patients with branch retinal vein occlusion and macular edema. BMC Ophthalmology, 2011, doi: 10.1186/1471-2415-11-29.
3. Khokhlova D.Yu., Drozdova E.A. The importance of the main markers of endothelial dysfunction in the development of macular edema in the occlusion of retinal veins. Sovremennye tekhnologii v oftal’mologii, 2016, no. 4, pp. 245-247 (in Russ.).
4. Shchuko A.G., Zlobin I.V., Yur’eva T.N., Ostanin A.A et al. Imbalance of intraocular cytokines in retinal vein occlusion and its relationship to efficacy of antiangiogenic therapy. Vestnik oftal’mologii, 2015, vol. 131, no. 2, pp. 50-58 (in Russ.).
5. Murakami T., Tsujikawa A., Miyamoto K. et al. Relationship between perifoveal capillaries and pathomorphology in macular edema associated with branch retinal vein occlusion. Eye, 2012, pp. 771-780.
6. Noma H., Funatsu H., Yamasaki M. Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular edema in branch retinal vein occlusion. Eye, 2008, vol. 22 (1), rr. 42-48.
7. Noma H. et al. Vitreous in flammatory factors and serous macular detachmentin branch retinalve in occlusion. Retina, 2012, vol. 32 (1), pp. 86-91.
8. Celik E., Doğan E., Turkoglu E.B. et al. Serous retinal detachment in patients with macular edema secondary to branch retinal vein occlusion. Arq. Bras. Oftalmol, 2016, pp. 9-11.
9. Hoeh A.E., Ruppenstein M., Ach T. OCT patterns of macular edema and response to bevacizumab therapy in retinal vein occlusion. Arch. Clin. Exp. Ophthalmol, 2010, pp. 1567-1572.
10. Drozdova E.A., Khokhlova D.Yu. Morphometric characteristics of the macular zone in patients with retinal vein occlusion according to optical coherence tomography. Meditsinskiy vestnik Bashkortostana, 2015, vol. 10, no. 2, pp. 64-67 (in Russ.).
11. Kazaryan A.A., Burladinova A.A., Lebenkova O.A. Morphological characteristics of the retinal macular zone in patients with retinal vein occlusion before and after treatment: preliminary results. Vestnik oftal’mologii, 2014, no. 1, pp. 12-17 (in Russ.).
12. Bikbov M.M., Shevchuk N.E., Fayzrakhmanov R.R. et al. Local level of cytokines in various morphological variants of the neovascular membrane in patients with a moist form of age-related macular degeneration. Meditsinskiy al’manakh, 2014, no. 1 (31), pp. 66-68 (in Russ.)