E.I. KHADIEVA¹, S.P. YAKUPOVA², R.Z. ABDRAKIPOV³, N.V. ZHURAVLEVA⁴

 ¹Family Health LLC, Republic of Tatarstan, Kazan

²Kazan State Medical University, Kazan

³Republic Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Kazan

⁴I.N. Ulyanov Chuvash State University, Cheboksary

 Contact details:

Khadyeva E.I. – rheumatologist

Address: 15 Chistopolskaya St., Kazan, Russian Federation, tel.: +7-937-526-18-27, e-mail: lenakhadyeva25@gmail.com

 This article presents a clinical case in which a patient observed by neurologists with a diagnosis of neuropathy and treated with anticonvulsants and antidepressants developed new clinical manifestations and laboratory changes characteristic of systemic lupus erythematosus. A clinical version emerged that the neurological changes were the disease onset, followed by the development of the remaining clinical and laboratory symptoms (the diagnosis fully met the 2019 EULAR criteria — a score of 16 points, 10 points are sufficient to make a diagnosis). However, after a very short and low-dose therapy with methylprednisolone and hydroxychloroquine and withdrawal of anticonvulsants, there was a rapid recovery of specific antibodies and improvement of clinical symptoms, which allowed assuming drug-induced lupus erythematosus in this patient. Currently, the list of drugs that can cause this problem includes more than 100 drugs.

Key words: drug-induced lupus erythematosus, polyneuropathy, anticonvulsants.

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