Differential diagnosis of polycythemia
А.V. КОSTERINA
Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012
Коsterina A.V. — Assistant of the Department of Hospital Therapy, tel. +7-917-273-77-68, e-mail: avakost@mail.ru
The article presents the clinical and laboratory criteria of differences of primary and secondary polycythemia, causes and classification of secondary polycythemia. A clinical case of secondary polycythemia is presented, confirmed by laboratory tests (serum erythropoietin level, the definition of Jak2 V617F mutation).
Key words: polycythemia, erythropoietin, Jak2 V617F.
REFERENCES
- McMullin M.F. The classification and diagnosis of erythrocytosis. J. Lab. Hematol, Dec, 2008, 30 (6), pp. 447-59.
- Percy M.J., Beard M.E., Carter C., Thein S.L. Erythrocytosis and the Chuvash von Hippel-Lindau mutation. J. Haematol, Oct, 2003, 123 (2), pp. 371-2.
- Remacha A.F., Montserrat I., Santamaria A. et al. Serum erythropoietin in the diagnosis of polycythemia vera. A follow-up study. Haematologica, Jul-Aug, 1997, 82 (4), pp. 406-10.
- Rapado I., Albizua E., Ayala R., Hernández J.A., Garcia-Alonso L., Grande S. et al. Validity test study of JAK2 V617F and allele burden quantification in the diagnosis of myeloproliferative diseases. Ann Hematol, Sep, 2008, 87 (9), pp. 741-9.