I.N. POSOKHOV¹, E.A. PRASKURNICHIY^{1, 2}, A.V. SIMAKOV¹

¹A.I. Burnazyan State Scientific Center of the Russian Federation, Moscow

²Russian Federal Academy of Continued Medical Education, Healthcare Ministry of Russia, Moscow

  Contact details:

Posokhov I.N. — MD, Professor of the Therapy Department

Address: 23 Marshal Novikov St., Moscow, Russian Federation, 123098, tel.: +7-925-646-82-81, e-mail: igor@posohov.ru

The pathophysiological characteristics of isolated systolic hypertension in the young (ISHY) differ from those in the elderly, which is important for the choice of diagnostic and therapeutic strategies. Although there is no consensus among experts about ISHY, it has recently become obvious that this is a heterogeneous state, and, possibly, not spurious. The strategies for ISHY treatment described in the modern literature are discussed in this review.

Key words: arterial hypertension, the youth, diagnostics, treatment.

REFERENCES

1. Staessen J., Amery A., Fagard R. Isolated systolic hypertension in the elderly. J Hypertens., 1990; 8:393–405.
2. Williams B., Mancia G., Spiering W. et al; ESC Scientific Document Group. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J, 2018, Sep 1, vol. 39 (33), pp. 3021–3104.
3. Palatini P., Rosei E.A., Avolio A. et al. Isolated systolic hypertension in the young: a position paper endorsed by the European Society of Hypertension. J Hypertens, 2018, Jun, vol. 36 (6), pp. 1222–1236.
4. Saladini F. Isolated systolic hypertension in the young. A heterogeneous condition. Minerva Med. 2021, May 14. DOI: 10.23736/S0026-4806.21.07627-8. Epub ahead of print.
5. Palatini P. The HARVEST. Looking for optimal management of young people with stage 1 hypertension. Panminerva Med, 2021, Mar 12. DOI: 10.23736/S0031-0808.21.04350-0. Epub ahead of print.
6. Yano Y., Lloyd-Jones D.M. Isolated Systolic Hypertension in Young and Middle-Aged Adults. Curr Hypertens Rep, 2016, Nov, vol. 18 (11), p. 78.
7. O’Rourke M.F., Adji A. Guidelines on Guidelines: focus on isolated systolic hypertension in youth. J Hypertens, 2013, vol. 31, pp. 649–654.
8. Nichols W.W., O’Rourke M.F., Vlachopoulos C. McDonald’s blood flow in arteries. 6th ed. London: Hodder Arnold, 2011.
9. O’Rourke M.F., Vlachopoulos C., Graham R.M. Spurious systolic hyper­tension in youth. Vasc Med, 2000, vol. 5, pp. 141–145.
10. Avolio A.P., Chen S.G., Wang R.P., Zhang C.L., Li M.F., O’Rourke M.F. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation, 1983, vol. 68, pp. 50–58.
11. Franklin S.S., Wong N.D. Hypertension and cardiovascular disease: contributions of the Framingham Heart Study. Glob Heart, 2013, vol. 8, pp. 49–57.
12. Franklin S.S., Gustin W. 4th, Wong N.D., Larson M.G., Weber M.A., Kannel W.B. et al. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation, 1997, vol. 96, pp. 308–315.
13. Posokhov I.N., Sharykin S.A., Trunina I.I. Izolirovannaya sistolicheskaya gipertenziya i ambulatornoe monitorirovanie tsentral’nogo arterial’nogo davleniya u detey i podrostkov [Isolated systolic hypertension and ambulatory central blood pressure monitoring in children and adolescents]. Nizhniy Novgorod: DEKOM, 2019. 96 p.
14. Yano Y., Stamler J., Garside D.B., Daviglus M.L., Franklin S.S., Carnethon M.R. et al. Isolated systolic hypertension in young and middle-aged adults and 31-year risk of cardiovascular mortality: the Chicago Heart Association Detection Project in Industry Study. J Am Coll Cardiol, 2015, vol. 65, pp. 327–335.
15. Aatola H., Koivistoinen T., Tuominen H., Juonala M., Lehtima¨ki T., Viikari J.S.A. et al. Influence of child and adult elevated blood pressure on adult arterial stiffness: The Cardiovascular Risk in Young Finns Study. Hypertension, 2017, vol. 70, pp. 531–536.
16. Mahmud A., Feely J. Spurious systolic hypertension of youth: fit young men with elastic arteries. Am J Hypertens, 2003, vol. 16, pp. 229–232.
17. McEniery C.M., Yasmin Maki-Petaja K.M., McDonnell B.J., Munnery M., Hickson S.S. et al., Anglo-Cardiff Collaboration Trial Investigators. The impact of cardiovascular risk factors on aortic stiffness and wave reflections depends on age: the Anglo-Cardiff Collaborative Trial (ACCT III). Hypertension, 2010, vol. 56, pp. 591–597.
18. McEniery C.M., Franklin S.S., Wilkinson I.B., Cockcroft J.R. Isolated systolic hypertension in the young: a need for clarity. J Hypertens, 2013, vol. 31, pp. 1911–1913.
19. McEniery C.M., Cockcroft J.R., Roman M.J., Franklin S.S., Wilkinson I.B. Central blood pressure: current evidence and clinical importance. Eur Heart J, 2014, vol. 35, pp. 1719–1725.
20. McEniery C.M., Yasmin Wallace S., Maki-Petaja K., McDonnell B., Shar-man J.E. et al., ENIGMA Study Investigators. Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults. Hypertension, 2005, vol. 46, pp. 221–226.
21. Julius S., Krause L., Schork N.J., Mejia A., Jones K.A., Van den Ven C. et al. Hyperkinetic borderline hypertension in Tecumseh, Michigan. J Hypertens, 1991, vol. 9, pp. 77–84.
22. Julius S., Jamerson K., Mejia A., Krause L., Schork N., Jones K. The Association of borderline hypertension with target organ damage and higher coronary risk. JAMA, 1990, vol. 264, pp. 354–358.
23. Julius S. Neurogenic component in borderline hypertension. In: Julius S, Esler MD, editors. The nervous system in arterial hypertension. Springfield, IL: Charles C Thomas, 1974, pp. 301–330.
24. Lund-Johansen P. Twenty-year follow-up of hemodynamics in essen­tial hypertension during rest and exercise. Hypertension, 1991, vol. 18 (5 suppl), pp. III54–III61.
25. Julius S., Randall O.S., Esler M.D., Kashima T., Ellis T., Bennet J. Altered cardiac responsiveness and regulation in the normal cardiac output type of borderline hypertension. Circ Res, 1975, vol. 36 (6 Suppl 1), pp. 199–207.
26. Grebla R.C., Rodriguez C.J., Borrell L.N., Pickering T.G. Prevalence and determinants of isolated systolic hypertension among young adults: the 1999–2004 US National Health And Nutrition Examination Survey. J Hypertens, 2010, vol. 28, pp. 15–23.
27. Strazzullo P., Barba G., Cappuccio F.P., Siani A., Trevisan M., Farinaro E. et al. Altered renal sodium handling in men with abdominal adiposity. A link to hypertension. J Hypertens, 2001, vol. 19, pp. 2157–2164.
28. Fisher J.P., Paton J.F. The sympathetic nervous system and blood pressure in humans: implications for hypertension. J Hum Hypertens, 2012, Aug, vol. 26 (8), pp. 463–475.
29. Bruno R.M., Ghiadoni L., Seravalle G., Dell’oro R., Taddei S., Grassi G. Sympathetic regulation of vascular function in health and diseas. Front Physiol, 2012, vol. 3, pp. 284.
30. Strazzullo P., Barbato A., Galletti F., Barba G., Siani A., Iacone R. et al. Abnormalities of renal sodium handling in the metabolic syndrome. Results of the Olivetti Heart Study. J Hypertens, 2006, vol. 24, pp. 1633–1639.
31. Schleich K.T., Smoot M.K., Ernst M.E. Hypertension in Athletes and Active Populations. Curr Hypertens Rep, 2016, Nov, vol. 18 (11), p. 77.
32. Berge H.M., Isern C.B., Berge E. Blood pressure and hypertension in athletes: a systematic review. Br J Sports Med, 2015, Jun, vol. 49 (11), pp. 716–723.
33. Sachtleben T., Fields K.B. Hypertension in the athlete. Curr Sports Med Rep, 2003, Apr, vol. 2 (2), pp. 79–83.
34. Stergiou G.S., Palatini P., Parati G., O’Brien E., Januszewicz A., Lurbe E., Persu A., Mancia G., Kreutz R. European Society of Hypertension Council and the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability. 2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement. J Hypertens, 2021, Mar 11. Epub ahead of print.
35. Myers M.G., Asmar R., Staessen J.A. Office blood pressure measurement in the 21st century. J Clin Hypertens, 2018, vol. 20, pp.1104–1107.
36. Andreadis E.A., Geladari C.V., Angelopoulos E.T. The optimal use of automated office blood pressure measurement in clinical practice. J Clin Hypertens (Greenwich), 2020, Apr, vol. 22 (4), pp. 555–559. Epub 2020 Feb 28.
37. Parati G., Stergiou G.S., Asmar R., Bilo G., de Leeuw P., Imai Y. et al., ESH Working Group on BP Monitoring. European Society of Hypertension guidelines for BP monitoring at home: a summary report of the Second International Consensus Conference on Home BP Monitoring. J Hyper- tens, 2008, vol. 26, pp. 1505–1526.
38. Stergiou G.S., Parati G., Mancia G. editors. Home blood pressure monitoring. Updates in hypertension and cardiovascular protection. European Society of Hypertension. Springer 2019. ISBN 978-3-030-23065-4, available at: https://www.springer.com/gp/book/9783030230647
39. Hinman A.T., Engel B.T., Bickford A.F. Portable blood pressure recorder. Accuracy and preliminary use in evaluating intradaily variations in pressure. Am Heart J, 1962, May, vol. 63, pp. 663–668.
40. Kulkarni S. Hypertension management in 2030: a kaleidoscopic view. J Hum Hypertens, 2020, Nov 2, pp. 1–6. DOI: 10.1038/s41371-020-00438-8. Epub ahead of print.
41. Allen N.B., Siddique J., Wilkins J.T., Shay C., Lewis C.E., Goff D.C. et al. Blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age. JAMA, 2014, vol. 311, pp. 490–497.
42. Wills A.K., Lawlor D.A., Muniz-Terrera G., Matthews F., Cooper R., Ghosh A.K. et al., FALCon Study Team. Population heterogeneity in trajectories of midlife blood pressure. Epidemiology, 2012, vol. 23, pp. 203–211.
43. Tielemans S.M., Geleijnse J.M., Menotti A., Boshuizen H.C., Soedamah-Muthu S.S., Jacobs D.R. Jr et al. Ten-year blood pressure trajectories, cardiovascular mortality, and life years lost in 2 extinction cohorts: the Minnesota Business and Professional Men Study and the Zutphen Study. J Am Heart Assoc, 2015, vol. 4, p. e001378.
44. Omboni S., McManus R.J., Bosworth H.B., Chappell L.C., Green B.B., Kario K. et al. Evidence and recommendations on the use of telemedicine for the management of arterial hypertension: an international expert position paper. Hypertension, 2020, vol. 76, pp. 1368–1383.
45. Saladini F., Fania C., Mos L., Mazzer A., Casiglia E., Palatini P. Office pulse pressure is a predictor of favourable outcome in young-to-middle- aged subjects with stage 1 hypertension. Hypertension, 2017. Epub ahead of print.
46. Lurbe E., Torro M.I., Alvarez-Pitti J., Redon P., Redon J. Central blood pressure and pulse wave amplification across the spectrum of periph- eral blood pressure in overweigh tandobeseyouth. J Hypertens, 2016, vol. 34, pp. 1389–1395.
47. Kollias A., Lagou S., Zeniodi M.E., Boubouchairopoulou N., Stergiou G.S..Association of central versus brachial blood pressure with target- organ damage: systematic review and meta-analysis. Hypertension, 2016, vol. 67, pp. 183–190.
48. Saladini F., Mos L., Casiglia E., Malipiero G., Mazzer A., Palatini P. Central blood pressure is an independent predictor of future hypertension in young to middle-aged stage 1 hypertensives. Blood Press, 2013, vol. 22, pp. 9–16.
49. Saladini F., Santonastaso M., Mos L., Benetti E., Zanatta N., Maraglino G., Palatini P., HARVEST Study Group. Isolatedsystolic hypertension of young-to-middle-age individuals implies a relatively low risk of developing hypertension needing treatment when central blood pressure is low. J Hypertens, 2011, vol. 29, pp. 1311–1319.
50. Hope S.A., Meredith I.T., Cameron J.D. Effect of non invasive calibration of radial waveforms on error in transfer-function-derived central aortic waveform characteristics. Clin Sci (Lond), 2004, vol. 107, pp. 205–211.
51. Hathway P., Butlin M., Turner M., Avolio A.P. PP.06.14, Comparative study of two ambulatory blood pressure monitors that use differing methods of calibration to determine central aortic blood pressure from the brachial waveform. Journal of Hypertension, 2015, June, vol. 33, pp. e181–e182.
52. Papaioannou T.G., Karageorgopoulou T.D., Sergentanis T.N., Protogerou A.D., Psaltopoulou T., Sharman J.E. et al. Accuracy of commercial devices and methods for noninvasive estimation of aortic systolic blood pressure a systematic review and meta-analysis of invasive validation studies. J Hypertens, 2017, vol. 35, pp. 894–896.
53. Sharman J.E., Avolio A.P., Baulmann J., Benetos A., Blacher J., Blizzard C.L. et al. Validation of noninvasive central blood pressure devices: ARTERY Society task force consensus statement on protocol stan- dardization. Eur Heart J, 2017, vol. 38, pp. 2805–2812.
54. Cheng H.M., Chuang S.Y., Sung S.H., Yu W.C., Pearson A., Lakatta E.G. et al. Derivation and validation of diagnostic thresholds for central blood pressure measurements based on long-term cardiovascular risks. J Am Coll Cardiol, 2013, vol. 62, pp. 1780–1787.
55. Roman M.J., Devereux R.B., Kizer J.R., Okin P.M., Lee E.T., Wang W. et al. High central pulse pressure is independently associated with adverse cardiovascular outcome the strong heart study. J Am Coll Cardiol, 2009, vol. 54, pp. 1730–1734.
56. Herbert A., Cruickshank K., Laurent S., Boutouyrie P. On behalf of The Reference Values for Arterial Measurements Collaboration. Establish- ing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. Eur Heart J, 2014, vol. 35, pp. 3122–3133.
57. Vlachopoulos C., Xaplanteris P., Aboyans V. et al. The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis, 2015, Aug, vol. 241 (2), pp. 507–532.
58. Georgieva N., Borizanova-Petkova A., Kinova E., Goudev A. Is 24 hour central aortic pressure superior to single measurement of central aortic pressure in well controlled hypertensive patients. European Heart Journal, 2020, Now, vol. 41 (2), ehaa 946.2757
59. Neter J.E., Stam B.E., Kok F.J., Grobbee D.E., Geleijnse J.M. Influence of weight reduction on blood pressure: a meta-analysis of random- ized controlled trials. Hypertension, 2003, vol. 42, pp. 878–884.
60. Sacks F.M., Svetkey L.P., Vollmer W.M., Appel L.J., Bray G.A., Harsha D. et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH- Sodium Collaborative Research Group. N Engl J Med, 2001, vol. 344, pp. 3–10.
61. Townsend R.R., Wilkinson I.B., Schiffrin E.L., Avolio A.P., Chirinos J.A., Cockcroft J.R. et al. Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific state- ment from the American Heart Association. Hypertension, 2015, vol. 66, pp. 698–722.
62. Hanssen H., Boardman H., Deiseroth A., Moholdt T., Simonenko M., Kränkel N., Niebauer J., Tiberi M., Abreu A., Solberg E.E., Pescatello L., Brguljan J., Coca A., Leeson P. Personalized exercise prescription in the prevention and treatment of arterial hypertension: a Consensus Document from the European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension. Eur J PrevCardiol, 2021, Mar 24, p. zwaa141. Epub ahead of print.
63. MacDonald H.V., Johnson B.T., Huedo-Medina T.B., Livingston J., Forsyth K.C., Kraemer W.J., Farinatti P.T., Pescatello L.S. Dynamic Resistance Training as Stand-Alone Antihypertensive Lifestyle Therapy: A Meta-Analysis. J Am Heart Assoc, 2016, Sep 28, vol. 5 (10), p. e003231.
64. Dhakam Z., Yasmin, McEniery C.M., Burton T., Brown M.J., Wilkinson I.B. A comparisonof atenolol and nebivolol in isolated systolic hypertension. J Hypertens, 2008, vol. 26, pp. 351–356.
65. Shahin Y., Khan J.A., Chetter I. Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta- analysis and meta-regression of randomised controlled trials. Atherosclerosis, 2012, vol. 221, pp. 18–33.