P.V. TOKAREV, L.V. PLAKSINA, I.N. CHEREZOVA, R.N. MAMLEEV, N.T. SAPHIN
Children Republican Clinical Hospital of the ministry of health of the Republic of Tatarstan
Kazan State Medical University

Tokarev Pavel Vladimirovich
Head of the Department of Oral and Maxillo-Facial Surgery
6 Glushko Str., apt.114, Kazan 420100
tel. 8-905-317-58-41, e-mail: facesurg@yandex.ru 

A solitary hemangioma with consumption thrombocytopenia (Kasabach – Merritt syndrome) is a rare in occurrence disease. Up to the present time diagnosis and treatment of this disease make certain difficulties. In this article we describe two clinical cases of Kasabach – Merritt syndrome.

Key words: Kasabach – Merritt syndrome, extensive hemangioma, thrombocytopenia, coagulopathy.

REFERENCES

1. Poljaev Ju.A., Postnikov S.S., Myl’nikov A.A., Garbuzov R.V., Narbutov A.G., Shimanovskij N.L. Novye vozmozhnosti v lechenii infantil’nyh gemangiom s pomoshh’ju propranolola // Mezhdunarodnyj medicinskij zhurnal. — 2012. — № 2. — S. 94-103.

2. Leaute-Labreze C., Prey S., Ezzedine K. Infantile haemangioma: Part II. Risks, complications and treatment // J. Eur Acad Dermatol Venerol. — 2011. — 25. — P. 1254-1260.

3. Oak S.N., Viswanath K. Management of hemangioma in children // Indian J. Dermatol. Venerol. Leprol. — 2006. — Vol. 18, № 72. — P. 1-4.

4. Oral propranolol therapy for infantile hemangiomas beyond the proliferation phase: a multicenter retrospective study // A. Zvulunov, C. McCuaig, I.J. Frieden et al. // Pediatr. Dermatol. — 2011. — Vol. 28, № 2. — P. 94-98.

5. Propranolol for severe hemangiomas of infancy // C. Leaute-Labreze, E. Dumas de la Roque, T. Hubiche et al. // N. Engl. J. Med. — 2008. — Vol. 358, № 24. — P. 2649-2651.

6. Kilkline C. Frieden I.J. Infantile hemangiomas: how common are they? A systematic review of the medical literature // Pediatr. Dermatol. — 2008. — Vol. 25. — P. 168-173.

7. Propranolol for infantile hemangiomas: early experience at a tertiary vascular anomalies center // L.M. Buckmiller, P.D. Munsun. U. Dyamenahalli et al. // Laryngoscope. — 2010. — Vol. 120. — P. 676-681.

8. Stroch C.H., Hoeger P.H. Propranolol for infantile hemangiomas: insights into the molecular mechanisms of actions // Br. J. Dermatol. — 2010. — Vol. 163, № 2. — P. 269-274.

9. Efficacy and safety of propranolol at first-line treatment for infantile hemangiomas // C. Schiestl, K. Neuhaus, S. Zoller et al. // Eur. J. Pediatr. — 2011. — Vol. 170, № 4. — P. 493-501.

10. Lronardi-Bee J., Batta K., O’Brien C., Bath-Hextall F.J. Intervenous for infantile hemangiomas (strawberry birth marks) of the skin // Cochrane Database Syst Rev. — 2011, Vol. 5: CD006545.