R.R. MUKHARYAMOVA¹, S.D. MAYANSKAYA¹, F.V. VALEYEVA¹, M.M. MANGUSHEVA¹, L.T. BAREYEVA², N.G. LATYPOVA²

¹Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012

²Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064 

Mukharyamova R.R. — postgraduate student of the Department of Therapy with Endocrinology course, tel. +7-917-900-76-70, e-mail: rmukharyamova@amtec-kazan.com¹

Mayanskaya S.D. — D. Med. Sc., Professor of the Department of Therapy with Endocrinology course, tel. +7-905-316-99-66, e-mail: smayanskaya@mail.ru¹

Valeyeva F.V. — D. Med. Sc., Professor of the Department of Therapy with Endocrinology course, tel. +7-917-255-55-79, e-mail: val-farida@yandex.ru¹

Mangusheva M.M. — Cand. Med. Sc., Assistant Professor of the Department of Therapy with Endocrinology course, tel. +7-917-297-56-06, e-mail: rmukharyamova@amtec-kazan.com¹

Bareyeva L.T. — Head of Endocrinology Department, tel. +7-917-913-53-32, e-mail: luizabar@yandex.ru²

Latypova N.G. — Doctor of the Department of Functional Diagnostics, tel. +7-917-776-45-59, e-mail: rmukharyamova@amtec-kazan.com² 

The aim of the research was to assess the diagnostic value of heart rate variability (HRV) indicators in diabetes cardiovascular autonomic neuropathy (DCAN) diagnostics in patients with diabetes mellitus of type 1. The study involved the examination of HRV (independent tests and 24-hour ECG) in 30 patients with type 1 diabetes. The prevalence of DCAN in patients with diabetes mellitus was 43%. Patients with DCAN had longer duration of diabetes, lower glomerular filtration rate and suffered from peripheral neuropathy more often than patients without DCAN. The ОНЧ, НЧ и ВЧ fluctuations reduced fasterthan the changes in vegetative tests, however in 85% of cases these changes were accompanied by at least one positive result of vegetative tests. The deep breathing test had the highest diagnostic value among the battery of cardiovascular tests.

Key words: diabetes cardiovascular autonomic neuropathy, type 1 diabetes mellitus, heart rate variability, diagnostic value, vegetative tests.

REFERENCES

1. Mukhtarova R.R. Early diagnosis of cardiovascular form of diabetic autonomic neuropathy. Prakticheskaya meditsina, 2013, vol. 1 (69), pp. 75-79 (in Russ.).

2. Muhr-Becker D., Ziegler A.G., Druschky A. et al. Evidence for specific auto-immunity against sympathetic and parasympathetic nervous tissues in Type 1 diabetes mellitus and the relation to cardiac autonomic dysfunction. Diabet. Med., 1998, vol. 15, pp. 467-472.

3. Vinik A.I., Maser R.E., Mitchell B.D. et al. Diabetic autonomic neuropathy. Diabetes Care, 2003, vol. 26, no. 5, pp. 1553-1579.

4. Ziegler D. Diabetic cardiovascular autonomic neuropathy: Prognosis, diagnosis and treatment. Diabetes Metab.Rev., vol. 1994, 10, pp. 339-383

5. Kempler P. Neuropathies (pathomechanism, clinical presentation, diagnosis, therapy). Springer, 2002. 208 p.

6. Vinik A.I., Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circula-tion, 2007, vol. 115, pp. 387-397.

7. Standards of Medical Care in Diabetes-2014. Diabetes Care, 2014, vol. 37.

8. Dedov I.I., Shestakova M.V. Algoritmy spetsializirovannoy meditsinskoy po-moshchi bol’nym sakharnym diabetom [Algorithms specialized medical care to patients with diabetes]. 5-th edition. Moscow, 2011. 116 p.

9. Vinik A.I., Erbas T. Recognizing and treating diabetic autonomic neuropathy. Cleve Clin J Med., 2001, vol. 68 (9280, pp. 928-944.