Determination of the «Intima-media»complex thickness for screening of carotid stenosis
A.V. MAKSIMOV1,2, E.A. GAYSINA1, A.K. FEYSKHANOV1, R.M. NURETDINOV1, M.V. PLOTNIKOV1,2, Yu.E. TEREGULOV1
1Republican Clinical Hospital of Ministry of Health of the Republic of Tatarstan, 138 Orenburgskiy Trakt, Kazan, Russian Federation 420064
2Kazan State Medical Academy, 11 Butlerova St., Kazan,Russian Federation 420012
Maksimov A.V. — Cand. Med. Sc., Head of the Vascular Surgery Department № 1 of Republican Clinical Hospital, tel. +7-927-243-42-93, e-mail: maks.av@mail.ru1,2
Gaysina E.A. — cardio-vascular surgeon of the Vascular Surgery Department № 1, tel. +7-905-039-51-74, e-mail: kalbas77@yandex.ru1
Feyskhanov A.K. — cardio-vascular surgeon of the Vascular Surgery Department № 1, tel. +7-987-296-06-42, e-mail: aygizf@rambler.ru1
Nuretdinov R.M. — cardio-vascular surgeon of the Vascular Surgery Department № 1, tel. +7-927-407-19-02, e-mail: rifkat21@mail.ru1
Plotnikov M.V. — cardio-vascular surgeon of the Vascular Surgery Department № 1, tel.: (843) 237-32-76, +7-917-265-19-03,e-mail: plotnikov_mv@bk.ru1,2
Teregulov A.Y. — Cand. Med. Sc., Head of the Functional Diagnostics Department, tel. +7-917-264-70-04, e-mail: tereg2@mail.ru1
5000 extracranial arteries CDS protocols for the period from 2010 to 2012 were analyzed. The age ranged from 40 to 90 years old (average age — 58,9±0,15 years). Among them there were 2550 men and 2450 women. 4104 patients (82,1%) had no stenotic disease, 445 (8,9%) patients had small, 329 (6,6%) — moderate and 106 (2,1%) patients – significant ICA stenoses. 16 (0,3%) patients had ICA occlusion. CCA IM-thickness of less than 0,1 cm had 29,7% of patients, CCA IMT 0,11-0,14 cm — 50,6%; 0,15-0,19 cm had 16,9% patients, thickness of 0,2-0,24 cm had 2,5% of patients, and more than 0.25 cm CCA IMT had 0.2% of patients. There was revealed a significant positive correlation between the average thickness of CCA IMT and the degree of stenosis of the internal carotid artery (r=0,46; t=6,57; p<0,001).
The comparative economic analysis was performed of rationality of one-and two-stage screening of carotid stenosis in the population based on the calculation of identifying of one patient with this disease. The most feasible from economic point is conducting a two-stage screening: stage 1 — defining of IMT CCA, stage 2 — performing extracranialCDS for patients with CCA IMT of more than 0,14 cm.
Key words: screening, carotid stenosis, «Intima-media»complex.
REFERENCES
1. Paddok-Eliasziw L.M., Eliasziw M., Barr H.W., Barnett H.J. Long-term prognosis and the effect of carotid endarterectomy in patients with recurrent ipsilateral ischemic events. North American Symptomatic Carotid Endarterectomy Trial Group. Neurology, 1996, vol. 95 (5), rr. 1158-1162.
2. Natsional’nye rekomendatsii po vedeniyu patsientov s sosudistoy arterial’noy patologiey (Rossiyskiy soglasitel’nyy dokument). Chast’ 3. Brakhiotsefal’nye arterii [National guidelines for management of patients with vascular arterial pathology (Russian consensus document). Part 3. Brachiocephalic arteries]. Moscow: Angiologiya INFO, 2013. 73 p.
3. Meijer W.T., Hoes A., Rutgers W. et al. Peripheral arterial disease in the elderly: The Rotterdam Study. Arterioscler. Thromb. Vase. Biol., 1998, vol. 18, rr. 185-192.
4. Zheng Z.J., Sharrett A.R., Chambless L.E. et al. Association of ankle-brachial index with clinical coronary heart disease, stroke, and preclinical carotid and popliteal atherosclerosis: the ARIC study. Atherosclerosis, 1997, vol. 131, rr. 115-25.
5. Pujia A., Rubba P., Spencer M. P. Prevalence of extracranial carotid artery disease detectable by echo-Doppler in an elderly population. Stroke, 1992, vol. 23 (6), pp. 818-822.
6. Dempsey R.J., Diana A.L., Moore R.W. Thickness of carotid artery atherosclerotic plaque and ischemic risk. Neurosurgery, 1990, vol. 27 (3), pp. 343-348.