O.K. POZDEEV¹, N.Yu. KURYAEVA², A.Z. VALIULLINA², V.A. KARAGANOV², M.P. SHULAEVA¹

¹Kazan State Medical Academy — Branch Campus of the RMACPE MOH Russia, 36 Butlerov Str., Kazan, Russian Federation, 420012

² Republic Clinical Infectious Hospital named after Prof. A.F. Agafonov, 54 Ershov Str., Kazan, Russian Federation, 420061

  Pozdeev O.K. — D. Med. Sc., Professor of the Department of Microbiology, tel. (843)233-34-78, e-mail: pozdeevoskar@rambler.ru

Kuryaeva N.Yu. — Deputy Chief Doctor for Laboratory Diagnostics, tel. +7-917-257-18-10

Valiullina A.Z. — bacteriologist, tel. +7-917-935-19-03, e-mail: alfaromeo603@gmail.ru

Karaganov V.A. — bacteriologist, tel. +7-904-679-80-45, e-mail: karovvl@yandex.ru

Shulaeva M.P. — Cand. Med. Sc., Associate Professor of the Department of Microbiology, tel. (843) 233-34-78, e-mail: shulaeva.m@mail.ru

The article views certain aspects of AmpC class β-lactamases synthesis by some species of Enterobacteriaceae family. The authors propose a simple and efficient method of AmpC β-lactamases detection, applicable in the routine practice of bacteriological laboratories. The means of detecting the ability to produce such enzymes are important for the adequate choice of antibacterial medications by an attending physician.

Key words: nosocomial infections, b-lactamases, enterobacteria, antimicrobic medications.

REFERENCES

1. World Health Organization. Antimicrobialresistance: Globalreportonsurveillance. World Health Organization. Geneva, Switzerland: 2014.
2. Chang H.-H., Cohen T., Grad Y., Hanage W.P., O’Brien T., Lipsitch M. Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens. MicrobiolMolBiol Rev.,2015; 79 (1): 101–116.
3. Exner M., Bhattacharya S., Christiansen B. et all. Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria? GMS Hyg Infect Control., 2017; 12: Doc05.
4. .Bell B., Schellevis F., Stobberingh E., Goossens H., Pringle M. A systematic review and meta-analysis of the effects of antibiotic consumption on antibioticresistance. BMC Infect Dis., 2014; 13:14.
5. Jacoby G. Amp C beta-lactamases. Clin Microbiol Rev., 2009;22 (1):161–82.
6. Blair J.M.A., Webber M.A., Baylay A.J., Ogbolu D.O., Piddock L.J.V. Molecular mechanisms of antibiotic resistance. Nat. Rev. Microbiol.,2015;13:42–51
7. Rodrнguez-Martнnez J. Fernбndez-Echauri P. Fernбndez-Cuenca F. et al. Characterization of an extended-spectrum AmpC cephalosporinase with hydrolysing activity against fourth-generation cephalosporins in a clinical isolate of Enterobacter aerogenes selected in vivo. J Antimicrob Chemother.,2012; 67 (1):64–68.
8. Navarro F., Mirу E., Mirelis B. Interpretive reading of enterobacteria antibiograms. Enferm Infecc Microbiol Clin., 2010;28 (9):638–45.