M.M. GUROVA¹, V.P. NOVIKOVA²

¹Belgorod State National Research University, Pobeda St., 85, Belgorod, Russian Federation, 308015

²V.A. Almazov Federal Centre of the Heart, Blood and Endocrinology, 2 Akkuratova St.,

Saint Petersburg, Russian Federation, 194156

Gurova M.M. — D. Med. Sc., Professor of the Department of Pediatrics with the Course of Surgical Diseases of Children, tel. (4722) 30-12-67, e-mail: itelv@mail.ru¹

Novikova V.P. — D. Med. Sc., Professor of the Department of Children Diseases, tel. (812) 702-37-22, e- mail: novikova-vp@mail.ru² 

The article deals with the results of medical examination carried out in 360 children with chronic gastroudenitis (CGD) associated with Helicobacter infection in the period of exacerbation as well as 90children 6 months after successful eradicative therapy,apart from traditional examination, concentration of microelements in the blood serum was determined and the parameters of oxidant and antioxidant status were evaluated. The qualitive and quantitative assessment the intestinal wall microflora was made in 30 children with CGD. The disturbances in the system of micro elemental homeostasis with the increasing level of the toxic microelements (arsenic, nickel, mercury, lead) and decreasing level of the essential microelements (copper, manganese, selenium, zink, iron) in the period of exacerbation were found. The disturbances above can be also seen in the period of remission due to the lower concentrations of such microelements as like copper, selenium and iron. The pathological chances determined were accompanied by the quantitative decrease of normaflora (Bifidobacterium, Luctobacterium, Propionibacterium) and excessive growth of theopportunistic flora (Clostridium family, , Streptococcus, Candida albicans)

Key words: chronic gastroduodenitis, children, microelemental status, disbyosis, pro- and antioxidant status.

 

 

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