T.R. KIREEV

Bashkir State Medical University, 3 Lenin Str., Ufa, Russian Federation, 450000

 Kireev T.R. ― Assistant of the Radiodiagnostics Depаrtment, e-mail: boarder_7@rambler.ru

Objective ― to study the state of cerebral blood flow and the dependence of structural-functional changes in peripheral arteries with brain lesions in elderly patients with arterial hypertension.

Material and methods. The study included 87 patients with arterial hypertension (AH) aged 60-65. The control group included 20 persons with normal tension and low cardiovascular risk ― 1.8±0.5%, comparable with patients with hypertension by age and sex. A comparative assessment was performed of peripheral vessels and hemodynamics parameters, affecting the degree of damage to the white matter of the brain.

Results. The study showed that remodeling of peripheral vessels takes place in arterial hypertension. The interrelation between carotid blood flow indicators and hemodynamic state with foci of brain gliosis transformation was revealed. The study of gliosis foci with magnetic resonance imaging (MRI) and ultrasound dopplerography (USDG) of cerebral vessels in elderly patients with hypertension provides additional information on the state of target organs for the purpose of timely correction of the revealed changes.

Key words: arterial hypertension, older age, magnetic resonance imaging, Fazekas scale.

(For citation: Kireev T.R. Comprehensive assessment of the brain status in elderly patients with arterial hypertension. Practical Medicine. 2018)

REFERENCES

1. Rubanenko A.O., Orekhova A.S. Age differences in the rigidity of the vascular wall in patients with arterial hypertension. Uspekhi gerontologii, 2016, vol. 29, no. 3, pp. 478-480 (in Russ.).
2. Chazova I.E., Oshchepkova E.V. The results of the implementation of the Federal Target Program for the Prevention and Treatment of Arterial Hypertension in Russia in 2002-2012. Vestnik Rossiyskoy akademii meditsinskikh nauk, 2013, no. 2, pp. 4-11 (in Russ.).
3. Golovanova E.D., Silaeva N.N., Kovalev D.Yu. Comparative evaluation of cerebral blood flow in elderly and senile patients with arterial hypertension and postinfarction cardiosclerosis. Klinich. gerontologiya, 2008, vol. 14, no. 9, pp. 73-74 (in Russ.).
4. Kravchenko M.A., Varakin Yu.Ya., Kuntsevich G.I. et al. Faktory riska, tserebrovaskulyarnaya i kardialʹnaya patologiya, vyyavlyaemye pri skrininge otkrytoy populyatsii [Risk factors, cerebrovascular and cardiac pathology detected during screening of an open population]. Kardionevrologiya: sb. st. i tez. II Nats. kongr. Moscow, 2012. Pp. 55-57.
5. Ostroumova O.D., Ostroumova T.M., Perepelov V.A. et al. The role of magnetic resonance imaging in detecting early signs of brain damage in hypertension. Ehffektivnaya farmakoterapiya, 2017, no. 33, pp. 44-50 (in Russ.).
6. Fazekas F., Chawluk J.B., Alavi A. et al. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. American journal of roentgenology, 1987, no. 149 (2), rr. 351-356.
7. Lin K., Lloyd-Jones D.M., Liu Y. et al. Potential Quantitative Magnetic Resonance Imaging Biomarkers of Coronary Remodeling in Older Hypertensive Patients. Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, no. 32, rr. 1742-1747.
8. Jennings J.R., Muldoon M.F., Ryan C. et al. Prehypertensive Blood Pressures and Regional Cerebral Blood Flow Independently Relate to Cognitive Performance in Midlife. J. Am. Heart. Assoc, 2017, 17; 6 (3), r. 48.
9. Kearney-Schwartz A., Rossignol P., Bracard S. et al. Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke, 2009, Apr, 40 (4), rr. 1229-36.