D.D. MUKHAMETOVA¹, E.N. BELOUSOVA¹, A.KH. ODINTSOVA², E.N. GABITOVA², R.R. SHAKIROV^1, 2, M.I. ZIGANSHIN², I.S. RAGINOV², A.R. YANGURAZOVA¹, A.M. GALIEVA¹

 ¹Kazan State Medical University, Kazan

²Republic Clinical Hospital, Kazan

  Contact details:

Mukhametova D.D. — PhD (medicine), assistant Lecturer of the Department of Hospital Therapy

Address: 138 Orenburgskiy trakt, Kazan, Russian Federation, 420064, tel.: +7 (843) 237-32-61, e-mail: muhdilyara@gmail.com

 The article presents a clinical case of a rare disease — primary intestinal T-cell lymphoma (PITL). A distinctive feature of PITL is the absence of typical clinical, laboratory and instrumental manifestations. This requires performing differential diagnosis with other diseases such as Crohn’s disease, chronic mesenteric ischemia and infections. The diagnostic standard of PITL is morphological verification. In this case, the diagnosis of PITL, NOS was made during the immunohistochemistry of the biopsy of the resected intestine.

Key words: primary intestinal T-cell lymphoma, Crohn’s disease, inflammatory bowel disease, non-Hodgkin’s lymphoma, intestinal lymphoma.

REFERENCES

1. Mashayekhi A., Quiroga E.F., Margolick J.F. et al. Intestinal T-cell lymphoma: A rare entity presenting with severe acute upper quadrant pain. Clin Case Rep, 2022, no. 10 (3), p. e05546. DOI: 10.1002/ccr3.5546
2. Xiang Y., Yao L. Analysis of 78 Cases of Primary Gastrointestinal Lymphoma. J Healthc Eng, 2022, p. 3414302. DOI: 10.1155/2022/3414302
3. Cazzola M. Introduction to a review series: The 2016 revision of the WHO classification of tumors of hematopoietic and lymphoid tissues. Blood, 2016, no. 127 (20), pp. 2361–2364. DOI: 10.1182/blood-2016-03-657379
4. Alaggio R., Amador C., Anagnostopoulos I. et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia, 2022, no. 36, pp. 1720–1748. DOI: 10.1038/s41375-022-01620-2
5. Al’myashev A.Z., Ul’yankina R.A., Skopin P.I. et al. Primary T-cell extranodal lymphoma associated with enteropathy, debuting with complications. Analysis of two own clinical observations and the reasons for their unfavorable outcome. Sibirskiy onkologicheskiy zhurnal, 2021, no. 20 (2), pp. 141–148 (in Russ.). DOI: 10.21294/1814-4861-2021-20-2-141-148
6. Fernandes T., Oliveira M.I., Castro R. Bowel wall thickening at CT: simplifying the diagnosis. Insights Imaging, 2014, vol. 5, pp. 195–208. DOI: 10.1007/s13244-013-0308-y
7. Yang H., Zhang H., Liu W. et al. Differential Diagnosis of Crohn’s Disease and Ulcerative Primary Intestinal Lymphoma: A Scoring Model Based on a Multicenter Study. Front Oncol, 2022, vol. 12, p. 856345. DOI: 10.3389/fonc.2022.856345
8. Bautista-Quach M.A., Ake C.D., Chen M. et al. Gastrointestinal lymphomas: morphology, immunophenotype and molecular features. J Gastrointest Oncol, 2012, vol. 3 (3), pp. 209–225.
9. Tang X.-F., Yang, L. Intestinal T-cell and NK/T-cell lymphomas: A clinicopathological study of 27 Chinese patients. Annals of Diagnostic Pathology, 2018, vol. 37, pp. 107–117. DOI: 10.1016/j.anndiagpath.2018.10.004
10. Nishimura M.F., Nishimura Y., Nishikori A. Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches. Cancers, 2021, vol. 13, p. 5774. DOI: 10.3390/cancers13225774
11. Fernandes T., Oliveira M.I., Castro R. et al. Bowel wall thickening at CT: simplifying the diagnosis. Insights Imaging, 2014, vol. 5, pp. 195–208. DOI: 10.1007/s13244-013-0308-y
12. Kim S.J., Choi C.W., Mun Y.-C. Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL). BMC Cancer, 2011, vol. 11, p. 321.