I.S. GRISHIN¹, N.I. MAKSIMOV¹, N.S. GRISHINA²

 ¹Izhevsk State Medical Academy, Izhevsk

²Republican Clinical and Diagnostic Center, Izhevsk

Contact details:

Grishin I.S. — Assistant Lecturer, Department of State Medicine with a course in Cardiology and functional diagnostics

Address: 281 Kommunarov St., Izhevsk, Russian Federation, 426034, tel.: +7-912-020-01-96, e–mail: V9120200196@yandex.ru

List of abbreviations:

GFI — global function index

MIwoCAO — myocardial infarction without coronary artery obstruction

MIwCAO — myocardial infarction with coronary artery obstruction

SIRI — systemic inflammatory response index

CG — coronarography

EDV — end-diastolic volume

ESV — end-systolic volume

NLR — neutrophil-lymphocyte ratio

PLI — platelet-lymphocyte ratio

TTECG — transthoracic echocardiography

SV — stroke volume

HD LPC — high-density lipoprotein cholesterol

The purpose — to evaluate the indicators of inflammation of a general blood test in the acute period of myocardial infarction with or without obstruction of the coronary arteries.

Material and methods. The study included 170 patients diagnosed with myocardial infarction. According to the CG data, the patients were divided into 2 groups: 1 — MIwoCAO, n = 73; 2 — MIwCAO, n = 97. According to the IGF level (> 31.2% and < 31.2%), the patients were divided into 2 subgroups: 1 — low GFI, n = 94 and 2 — normal GFI, n = 76. According to the results of a gemeral blood test, the main indicators of systemic inflammation were calculated — NLR, TLR, monocytes/HD LPC, SIRI. The results of the two groups were compared.

Results. In patients with MIwCAO, the level of leukocytes was statistically significantly higher — 12.1 vs. 9.9, erythrocytes — 5.0 vs. 4.76 and platelets — 257 vs. 235. Leukocytosis is mainly represented by neutrophils — 8.8 vs. 6.55. SIRI was higher in patients with MIwCAO (933 vs. 728). Indicators of the inflammatory process were statistically significantly higher in patients with low LV GFI due to higher numbers of leukocytes (11.1 vs. 10.1), neutrophils (8 vs. 7.3), lymphocytes in % ratio (19 and 21.3), higher NLR (3.97 vs. 3.3), and higher levels of monocytes/HD LPC (0.71 vs. 0.6). Patients with atherosclerosis and low GFI had higher levels of leukocytes compared with patients without obstructive lesion (12.2 vs. 10.15), neutrophils (9.5 vs. 7), as well as higher levels SIRI (1015 vs. 794).

Conclusions. 1. Patients with MIwoCAO have lower levels of leukocytes, neutrophils, platelets, and SIRI. 2. Patients with low left ventricular GFI show higher rates of systemic inflammation due to leukocytes, neutrophils, NLR, and the monocytes/HD LPC index.

Key words: myocardial infarction without coronary artery obstruction, myocardial infarction with coronary artery obstruction, systemic inflammatory reaction index, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, myocardial infarction.

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