F.I. GUSYAKOV¹, D.V. MOROZOV¹, E.A. MOROZOVA¹, V.F. PRUSAKOV¹, M.V. BELOUSOVA¹, M.A. UTKUZOVA¹, O.V. KNYAZEVA¹, A.A. MADYAKINA¹, N.V. CHERNIKOVA²

¹Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan

²NEO Medical Center, Kazan

 Contact details:

Morozov D.V. — PhD (medicine), Associate Professor of the Department of Pediatric Neurology

Address: 11 Galeev St., Russian Federation, Kazan, 420061, tel.: +7 (843) 273-49-09, e-mail: dimorozov84@gmail.com

The review is devoted to common epilepsy of childhood — childhood absence epilepsy. This epileptic syndrome debuts at pre-school age and is characterized by frequent seizures which may be underestimated by doctors due to the clinical features of a seizure. The seizures can debilitate a child and restrict socialization, as specific comorbidities in cognitive field are very common for child absence epilepsy. The etiology of neropsychiatric comorbidities is different. Seizures, epileptic discharges, as well as interictal epileptiform activity in the brain may cause neuropsychological impairments in children. Antiepileptic drugs are important in the development of neuropsychological impairments. The aim of this review was to actualize information on childhood absence epilepsy and stress the necessity to pay practitioner’s attention to common comorbidities in cognitive field.

Key words: childhood absence epilepsy, cognitive impairments, antiepileptic drugs, review.

REFERENCES

1. Turovskaya N.G. Epilepsy and mental development disorders: a review of scientific research results. Teoreticheskaya i eksperimental’naya psikhologiya, 2016, no. 9 (3), pp. 40–53.
2. Akhutina T.V., Melikyan Z.A. Neuropsychological testing: an overview of current trends. To the 110th anniversary of the birth of A.R. Luria. Klinicheskaya i spetsial’naya psikhologiya, 2012, no. 2, pp. 16–18 (in Russ.).
3. Davies-Eysenck M. Cognitive factors in epilepsy. Journal of Neurology, Neurosurgery & Psychiatry, 1952, vol. 15 (1), pp. 39–44.
4. Loveland N.T. Epileptic Personality and Cognitive Functioning. Journal of Projective Techniques, 1961, vol. 25 (1), pp. 54–68.
5. Dennis Dlugos, Shlomo Shinnar, Avital Cnaan et al. Pretreatment EEG in childhood absence epilepsy associations with attention and treatment outcome. Neurology, 2013, vol. 81 (2), pp. 150–156.
6. Cheng D., Yan X., Gao Z., Xu K., Zhou X., Chen Q. Neurocognitive Profiles in Childhood Absence Epilepsy: A Focus on Cognitive Dysfunction Associated With the Frontal Lobe. Journal of Child Neurology, 2017, vol. 32 (5), pp. 46–52.
7. Senem Sezikli, Tuğba Argün, Betül Tekin. Frontal lobe cognitive functions and electroencephalographic features in juvenile myoclonic epilepsy. Epilepsy & Behavior, vol. 86, pp. 102–107.
8. Belén Abarrategui, Beatriz Parejo-Carbonell, Maria Eugenia GarcíaGarcía. The cognitive phenotype of idiopathic generalized epilepsy. Epilepsy & Behavior, vol. 89, pp. 99–104.
9. Cheng Dazhi, Yan Xiuxian, GaoZhijie, XuKeming, Chen Qian. Attention Contributes to Arithmetic Deficits in New-Onset Childhood Absence Epilepsy. Frontiers in Psychiatry, 2007, vol. 166, pp. 127–139.
10. Caplan R., Siddarth P., Stahl L., Lanphier E., Vona P., Gurbani S., Koh S., Sankar R., Shields W.D. Childhood absence epilepsy: Behavioral, cognitive, and linguistic comorbidities. Epilepsia, 2008, vol. 49, pp. 1838–1846.
11. Filho G.M., Mazetto L., da Silva J.M., Caboclo L.O., Yacubian E.M. Psychiatric comorbidity in patients with two prototypes of focal versus generalized epilepsy syndromes. Seizure, 2011, vol. 20 (5), pp. 383–386.
12. Iqbal N., Caswell H., Muir R., Cadden A., Ferguson S., Mackenzie H., Watson P., Duncan S. Neuropsychological profiles of patients with juvenile myoclonic epilepsy and their siblings: An extended study. Epilepsia, 2015, vol. 56, pp. 1301–1308.
13. Vega C., Guo J., Killory B., Danielson N., Vestal M., Berman R., Martin L., Gonzalez J.L., Blumenfeld H., Spann M.N. Symptoms of anxiety and depression in childhood absence epilepsy. Epilepsia, 2011, vol. 52, pp. e70–e74.
14. Pavone A., Niedermeyer E. Absence seizures and the frontal lobe. Clinical Electroencephalography, 2000, vol. 31 (3), pp. 153–156.
15. Niedermeyer E. Primary (Idiopathic) Generalized Epilepsy and Underlying Mechanisms. Clinical Electroencephalography, 1996, vol. 27 (1), pp. 1–21.
16. Lie C.H., Specht K., Marshall J.C., Fink G.R. Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test. Neuroimage, 2006, vol. 30, pp. 1038–1049.
17. Killory B.D., Bai X., Negishi M. et al. Impaired attention and network connectivity in childhood absence epilepsy. Neuroimage, 2011, vol. 56 (4), pp. 2209–2217.
18. D’Agati Elisa et al. Attention and executive functions profile in childhood absence epilepsy. Brain and Development, vol. 34 (4), pp. 812–817.
19. Bai X., Guo J., Killory B. et al. Resting functional connectivity between the hemispheres in childhood absence epilepsy. Neurology, 2011, vol. 76 (23), pp. 1960–1967.
20. Carney P.W., Masterton R.A., Flanagan D. et al. The frontal lobe in absence epilepsy: EEG-fMRI findings. Neurology, 2012, vol. 78 (15), pp. 1157–1165.
21. Serpil Yıldız-Çoksan, Aslı Aslan, Sami Çoksan et al. Cognitive profile and academic achievement of children with absence epilepsy. Epilepsy & Behavior, 2019, vol. 95, pp. 95–99.
22. Sudha Kilaru Kessler, Emily McGinnis. A Practical Guide to Treatment of Childhood Absence Epilepsy. Pediatric Drugs, 2019, vol. 21, pp. 15–24.
23. Glauser T.A. et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months. Epilepsia, 2013, vol. 54, pp. 141–155.
24. Sun W., Wang Y., Wang W., Wu X. Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential. Int. J. Psychophysiol, 2017, vol. 68, pp. 235–241.
25. Donati F., Gobbi G., Campistol J., Rapatz G., Daehler M., Sturm, Y. et al. The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures. Seizure, 2007, vol. 16, pp. 670–679.
26. Masur D., Shinnar S., Cnaan A., Shinnar R.C., Clark P., Wang J., Weiss E.F., Hirtz D.G., Glauser T.A. Childhood Absence Epilepsy Study Group. Neurology, 2013, vol. 81 (18), pp. 1572–1580.
27. IJff D.M., van Veenendaal T.M., Debeij van Hall M.H., Jansen J.F.A., de Louw A.J.A., Majoie M.H.J., Aldenkamp A.P. The Cognitive Profile of Ethosuximide in Children. Pediatric Drugs, 2016, vol. 18 (5), pp. 379–385.
28. Verena Brodbecka, Verena Jansena, Urban Fietzeka, Christian Muehea, Gabriele Weberb, Florian Heinena. Long-term profile of lamotrigine in 119 children with epilepsy. European Journal of Paediatric Neurology, 2006, vol. 10 (3), pp. 135–141.
29. Pressler R.M., Binnie C.D. Effect of Lamotridgine on cognition in children with epilepsy. Neurology, 2006, vol. 66, pp. 1495–1499.
30. Sirén A., Kylliäinen A., Tenhunen M., Hirvonen K., Riita T., Koivikko M. Beneficial effects of antiepileptic medication on absence seizures and cognitive functioning in children. Epilepsy & Behavior, 2007, vol. 11 (1), pp. 85–91.