N.G. SHAMSUTDINOVA¹, E.R. KIRILLOVA¹, D.M. GAYSINA¹, A.M. FATYKHOVA¹, E.V. DYAKOVA², N.S. SPIRIDONOVA², L.I. MINGAZOVA²

 ¹Kazan State Medical University, Kazan,

²Republic Clinical Hospital of the Republic of Tatarstan, Kazan, Russian Federation

Contact details:

Shamsutdinova N.G. — PhD (medicine), Assistant Lecturer of the Hospital Therapy Department

Address: 49 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7-904-763-83-72, e-mail: nailya@e-diva.ru

Bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) lead to chronic hypoxia associated with cognitive impairment drastically worsening the quality of life of patients.

The purpose — to study the degree of cognitive impairment in patients with bronchial asthma and COPD hospitalized in the Pulmonology Unit of Republic Clinical Hospital.

Material and Methods. The study included 27 patients divided into two groups: 20 patients with bronchial asthma and 7 patients with COPD. All the participants were subjected to spirometry, pulse oximetry, and 6-minute walking test. Assessment of cognitive functions was carried out with MoCA test, MMSE questionnaire, and Mini-Cog test.

Results. No connection between gender and cognitive functions tests and between the diseases and cognitive functions tests were found with Mann — Whitney test. However, after the correlation analysis was performed, it revealed an association of Mini-Cog test results and pulmonary failure degree (p = 0,091083). Analysis of the correlation between cognitive disorders and pulmonary failure showed that the degree of pulmonary failure correlates with the Mini-Cog test results (p < 0,01). It proves the interconnection between cognitive deficit and pulmonary failure. Patients with bronchial obstructive syndrome showed a reliable correlation of cognitive disorders with age (p < 0,008) and pulmonary failure (р < 0,04). The research proved that patients with pulmonary failure degree 2 have more expressed cognitive disorders than patients with pulmonary failure degree 1.

Conclusion. In patients with asthma and COPD the cognitive impairment was diagnosed, its severity correlating with the degree of pulmonary failure.

Key words: cognitive disorders, pulmonary failure, bronchial asthma, COPD, hypoxia.

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