L.N. SUDUTKINA, V.V. BAITYAKOV

Mordovia State University named after N.P. Ogareva, Medical School, 26a Ulyanov St., Saransk, Russian Federation, 430032

Sudutkina L.N. — postgraduate student of the Department of Hospital Therapy, tel.: +7-937-512-58-33, (8342) 32-24-56, e-mail: sudutln@yandex.ru

Baityakov V.V. — D. Med. Sc., Associate Professor of the Course of Skin and Venereal Diseases, tel.: +7-917-698-49-57, (8342) 32-23-80, e-mail: baityakov@rambler.ru

The increase of atopic dermatitis incidence in adults causes actuality of comprehensive discussion on the background of dermatitis during pregnancy. The article presents data of the survey of 90 pregnant women with atopic dermatitis in acute stage. The clinical and anamnestic features of these patients are characterized. The factors contributing to the aggravation of this disease and affecting the severity of the disease are analyzed. The problems of atopic dermatitis complications in pregnant women are viewed. The study established differences in the course of atopic dermatitis depending on the period of gestation. New data on the prevalence of lesions in I trimester are obtained.

Key words: atopic dermatitis, pregnancy, clinical features.

 

 

REFERENCES

1. Sergeev Yu.V., Novikov D.K., Karaulov A.V. et al. Atopic dermatitis: pathogenesis. Immunopatologiya, allergologiya, infektologiya, 2001, no. 3, pp. 61-73 (in Russ.).

2. Smirnova G.I. Sovremennaya kontseptsiya lecheniya atopicheskogo dermatita [The modern concept of treatment of atopic dermatitis]. Moscow: Prima-Tsentr, 2006. 132 p.

3. Williams H.C. Epidemiology of human atopic dermatitis – seven areas of notable progress and seven areas of notable ignorance. Vet. Dermatol., 2013, vol. 24, pp. 3-9.

4. Ratsional’naya farmakoterapiya zabolevaniy kozhi i infektsiy, peredavaemykh polovym putem, pod red. A.A. Kubanovoy, V.I. Kisinoy [Rational pharmacotherapy skin diseases and infections, sexually transmitted diseases. Ed. A.A. Cubane, V.I. Kissina]. Moscow: Litterra, 2005. 882 p.

5. Sehgal V.N., Srivastava G., Dogra S. Atopic dermatitis: current options and treatment plan. Skinmed, 2010, no. 8 (6), pp. 335-344.

6. Kubo A., Nagao K., Amagai M. Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J. Clin. Invest., 2012, vol. 122, pp. 440-447.

7. McAleer M.A., Irvine A.D. The multifunctional role of filaggrin in allergic skin disease. J. Allergy Clin. Immunol., 2013, vol. 131, pp. 280-291.

8. Na S.Y., Roh J.Y., Kim J.M. et al. Analysis of Colonization and Genotyping of the Exotoxins of Staphylococcus aureus in Patients with Atopic Dermatitis. Ann. Dermatol., 2012, vol. 24, pp. 413-419.

9. Shchegoleva V.V. Osobennosti kliniki, patogeneza i podkhodov k terapii prostogo gerpesa, assotsiirovannogo s patologiey shchitovidnoy zhelezy: avtoref. dis. … kand. med. nauk [Clinical-pathogenesis and approaches to therapy of herpes simplex associated with thyroid cancer. Synopsis of dis. PhD med. sci.]. Novosibirsk, 2005. 26 p.

10. Gillgrass A.E., Tang V.A., Towarnicki K.M. et al. Protection against genital herpes infection in mice immunized under different hormonal conditions correlates with induction of vagina-associated lymphoid tissue. Virol., 2005, vol. 79, pp. 3117-3126.

11. Petukhova A.V. Kliniko-laboratornye osobennosti techeniya beremennosti i rodov u zhenshchin s allergicheskimi zabolevaniyami: avtoref. dis. … kand. med. nauk [Clinical and laboratory characteristics of the course of pregnancy and delivery in women with allergic diseases. Synopsis of dis. PhD med. sci.]. Perm, 2012. 23 p.

12. Kashirskaya E.N. Atopicheskiy dermatit i beremennost’ (osobennosti kliniki, gormonal’no-metabolicheskoy perestroyki, taktika vedeniya beremennykh kak pervichnaya profilaktika atopicheskogo dermatita u detey): avtoref. dis. … kand. med. nauk [Atopic dermatitis, and pregnancy (especially clinics, hormonal and metabolic adjustment, management of pregnant women as a primary prevention of atopic dermatitis in children). Synopsis of dis. PhD med. sci.]. Ekaterinburg, 1998. 18 p.

13. Alen’kina A.B. Dermatozy u beremennykh: avtoref. dis. … kand. med. nauk [Medicine in pregnancy. Synopsis of dis. PhD med. sci.]. Moscow, 2006. 19 p.

14. Hanifin J.M., Rajka G. Diagnostic features of atopic dermatitis. Acta Derm. Venerol. Suppl. (Stockh)., 1980, no. 92, pp. 44-47.

15. Stalder J.F., Taieb A. Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology, 1993, no. 186, pp. 23-31.

16. Federal’nye klinicheskie rekomendatsii po diagnostike i lecheniyu atopicheskogo dermatita [The federal guidelines for the diagnosis and treatment of atopic dermatitis]. Moscow, 2013. 28 p.

17. Dombrovskaya D.K. Techenie atopicheskogo dermatita i sostoyanie kozhnogo bar’era u beremennykh: avtoref. dis. … kand. med. nauk [For atopic dermatitis and the condition of the skin barrier in pregnant women. Synopsis of dis. PhD med. sci.]. Saint Petersburg, 2013. 15 p.

18. Suvorova K.N., Anton’ev A.A., Dovzhanskiy S.I. Atopicheskiy dermatit []. Saratov, 1989. Pp. 141-152.

19. Mal’tsev K.A., Bakhtilin V.Ya., Sidorova S.N. Kliniko-laboratornaya kharakteristika neyrodermita u beremennykh zhenshchin i sostoyanie zdorov’ya ikh detey [Clinical and laboratory characteristics of neurodermatitis in pregnant women and the health of their children]. Patogenez, klinika i lechenie khronicheskikh dermatozov i bolezney, peredavaemykh polovym putem. Sverdlovsk, 1990. Pp. 163-171.

20. Tetruashvili N.K. The role of immune interactions in the early stages of physiological pregnancy and habitual abortion. Immunologiya, 2008, no. 2, pp. 124-129 (in Russ.).

21. Sidel’nikova V.M. Podgotovka i vedenie beremennosti u zhenshchin s privychnym nevynashivaniem: metod. posobiya i klin. protokoly [Preparation and maintenance of pregnancy in women with recurrent pregnancy loss: a method. benefits and the wedge. protocols]. Moscow: MEDpress-inform, 2011. 224 p.