A.V. TIKHANKOVA, A.V. BORSUKOV

Smolensk State Medical University, Smolensk

  Contact details:

Tikhankova A.V. — post-graduate student of Scientific-research laboratory «Diagnostic research and low-invasive techniques»

Address: 28 Krupskaya St., Russian Federation, Smolensk, 214019, tel.: +7 (4812) 63-97-57, e-mail: annatikh67@mail.ru

 The purpose was to determine the diagnostic and prognostic value of contrast-enhanced ultrasound (CEUS) in patients with chronic viral hepatitis B and C.

Material and methods. On the basis of Clinical hospital № 1 in Smolensk from 2018 to 2019, 146 people with chronic viral hepatitis and 65 people with unchanged liver parenchyma as a control group were included in the study. All patients were examined wih CEUS with 1.0 ml of contrast agent with subsequent evaluation of quantitative parameters in the proximal and distal areas.

Results. Statistical data processing showed that the differences in quantitative parameters (Δ) in the proximal and distal areas have the largest predictive value in the diagnosis of liver parenchyma lesions.

Conclusion. CEUS is a non-invasive diagnostic liver pathology method that allows identifying the chronic viral hepatitis decompensation by evaluating the quantitative parameters in combination with the main diagnostic methods of chronic viral hepatitis.

Key words: contrast-enhanced ultrasound (CEUS), contrast agent, chronic viral hepatitis.

REFERENCES

1. Claudon M., Dietrich C.F., Choi B.I. et al. Guidelines and good clinical practice recommendations for Contrast Enhanced Ultrasound (CEUS) in the liver ― update 2012: A WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol, 2013, vol. 39 (2), pp. 187−210. DOI: 10.1016/j.ultrasmedbio.2012.09.002
2. Claudon M., Dietrich C.F., Choi B.I. et al. Clinical guidelines for ultrasound examination of the liver using contrast agents. Revision from 2012. WFUMB-EFSUMB Initiative with representation of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ul’trazvukovaya i funktsional’naya diagnostika, 2017, no. 1, pp. 81–116 (in Russ.).
3. Weskott H-P. Kontrastnaya sonografiya. 1-e izd. [Contrast sonography. 1st ed.]. Bremen: UNI-MED, 2014. Pp. 16–34.
4. Sencha A.N., Morgunov M.S., Patrunov Yu.N. et al. Ul’trazvukovoe issledovanie s ispol’zovaniem kontrastnykh preparatov [Ultrasound examination using contrast agents]. Moscow: Vidar-M; 2015. Pp. 14–31.
5. Cosgrove D.O. Contrast – enchanced ultrasound of liver lesions. Ultrasound Med Biol, 2010, vol. 36 (12), p. 2146; author reply 2146–2147. DOI: 10.1016/j.ultrasmedbio.2010.06.011
6. Borsukov A.V., Bueverov A.O., Tikhankova A.V. Semi-quantitative assessment of contrast-enhanced ultrasound examination in chronic viral hepatitis. Doktor. Ru, 2019, vol. 8, no. 163, pp. 28–34 (in Russ.). DOI: 10.31550/1727-2378-2019-163-8-28-34
7. Kuntz E., Kuntz H-D. Hepatology: principles and practice: 2nd edition. Springer Medizin Verlag Heidelberg, 2006. Pp. 391–410; 691–749.
8. Shiff Yudzhin R. Virusnye gepatity i kholestaticheskie zabolevaniya. Seriya «Bolezni pecheni po Shiffu» [Viral hepatitis and cholestatic diseases. Series «Liver diseases according to Schiff»]. Moscow: GEOTAR-Media, 2010. Pp. 185–350.
9. Tsyrkunov V.M., Matievskaya N.V., Lukashik S.P. HCV-infektsiya [HCV infection]. Minsk: Asar, 2012. Pp. 69–91.
10. Petr A. Naglyadnaya meditsinskaya statistika: uchebnoe posobie [Visual medical statistics: textbook]. Moscow: GEOTAR-Media, 2009. Pp. 64–65.
11. Lang T., Al’tman D. Fundamentals of the description of statistical analysis in articles published in biomedical journals. Manual «Statistical Analysis and Methods in Published Literature (SAMPL)». Meditsinskie tekhnologii. Otsenka i vybor, 2014, vol. 1, no. 15, pp. 11–16 (in Russ.).