V.V. EGOROV^1,2, G.P. SMOLYAKOVA^1,2, T.I. GOKHUA¹, T.V. BORISOVA¹

¹Khabarovsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 211 Tikhookeanskaya Str., Khabarovsk, Russian Federation, 680033

²Postgraduate Institute for Public Health Workers, 9 Krasnodarskaya Str., Khabarovsk, Russian Federation, 680000

 Egorov V.V. — D. Med. Sc., Professor, Director, Head of the Department of Ophthalmology of Postgraduate Institute for Public Health Workers, tel. (4212) 22-51-21, e-mail: naukakhvmntk@mail.ru

Smolyakova G.P. — D. Med. Sc., Professor, ophthalmologist of the Clinical-Expert Department, Professor of the Ophthalmology Department of Postgraduate Institute for Public Health Workers, tel. (4212) 22-51-21, e-mail: naukakhvmntk@mail.ru

Gokhua T.I. — physiotherapist, tel. (4212) 72-27-92, e-mail: naukakhvmntk@mail.ru

Borisova T.V. — Head of the Physiotherapy Department, tel. (4212) 72-27-92, e-mail: naukakhvmntk@mail.ru

 Analysis was made of the results of treatment of patients with bacterial keratitis (BK) by incorporating magnetophotophoresis of longidaza into their complex therapy. 28 patients with BK aged from 28 to 57 years were examined; the majority of patients had BK of moderate severity (19 people), some patients had BK of high severity (9 people). The causative agent of the disease according to the results of bacteriological studies was S. aureus (16 people), less often Pseudomonas aeruginosa (8 people) and mixed mikloflora S.epidermidis and Escherichia coli (4 people). All patients underwent irrigation with lacrimal-nasal antiseptics and standard systemic and local antibiotic therapy. From the first day of hospitalization, 16 patients (main group) underwent magnetophotophoresis of longidaza; 12 patients (control group) — magnetophototherapy without longidaza. The magneto-laser complex «AMO-ATOS» and «LAST-01» were used. As early as after the first 3-4 sessions of magnetophotophoresis of longidaza the patients of the main group reported disappearance of pain in the eye, improvement of visual acuity. In patients of the control group purging of the corneal defect from necrotic masses and resorption of the inflammatory exudate in the anterior chamber occurred 3-4 days later than in the main group. Evidence was obtained that the therapeutic effectiveness of complex therapy with inclusion of magnetophotophoresis of longidaza in patients of the main group significantly exceeds the results obtained in the control group (p<0.05).

Key words: physiotherapy, complex therapy, bacterial keratitis, magnetophotophoresis of longidaza.

References

1. Sidikov Z.U., Mirajubova O.A. Efficiency of therapeutic keratoplasty in purulent corneal ulcers. Questions of clinical ophthalmology: abstract boo, 1980, pp. 40-42. (in Russ.).
2. Volkovich T.K., Korolkova N.K., Khoroshenkaya N.V. Bacterial keratitis: etiology, pathogenesis. Vestnik of Vitebsk state medical university, 2011, vol. 10, no. 3, 6-11. (in Russ.).
3. Shaimova V.A. Bacterial keratitis. Clinical and immunological features of the course, prognosis, treatment of various forms of the disease: Abstract of Med. Sc. D. Dissertation, 2007. 44 p. (in Russ.).
4. Maichuk Yu.F. Eye infections. Russian medical journal, 1999, no. 1, pp. 7. (in Russ.).
5. Shaimova V.A. Peroxide oxidation of lipids and antioxidant protection in eye disease. Annals of Ophthalmology, 2002; vol. 118, no. 3, pp. 56-57. (in Russ.).
6. Kasparova E.A. Purulent corneal ulcers: clinical presentation, diagnosis and conservative treatment. Annals of Ophthalmology, 2015, no. 6, pp. 106-119. (in Russ.).
7. Kasparov A.A. Ophthalmoherpes. Moscow, Medicine, 1994, pp. 106-108. (in Russ.).
8. Maychuk D.Yu., Vasilyeva O.A., Russu L.I., Mezentseva M.V. Clinical and immunological comparisons of therapeutic regimensf for corneal infiltrates secondary to adenoviral keratoconjunctivitis. Annals of Ophthalmology, 2015, no. 4, pp. 49-55. (in Russ.).
9. Ulaschik VS Physico-pharmacological methods of treatment and prevention, 1979. 223 p. (in Russ.).
10. Chesnokova N.B. The role of proteolytic enzymes and their inhibitors in pathology of cornea: Abstract of Med. Sc. D. Dissertation, 1991. 34 p. (in Russ.).
11. Sosin I.N., Buyavykh A.G. Physical therapy of eye diseases, 1998. 248 p. (in Russ.).
12. Nazarenko K.A., Khoroshikh Yu.I., Zapuskalov I.V. Enzymotherapy in ophthalmology. Annals of Ophthalmology, 2006, no. 3, pp. 36-42. (in Russ.).
13. Dotsenko V.L., Nahikyan N.I., Solovyova N.I. et al. Proteolytic enzymes of lacrimal fluid as factors of the pathogenesis of chronic ulcers of the cornea. Questions of medical chemistry, 1990; no. 3, pp. 73-76. (in Russ.).
14. Orekhova E.M., Kongurova T.V., Lukyanova Т.V. et al. The use of Longidaza 3000 IU for diseases accompanied by pathology of connective tissue. Teaching manual for doctors. Moscow, 2008, 26 p. (in Russ.).
15. Kruglova L.S., Dvornikov A.S. Experience of application of photophoresis and phonophoresis with Longidiaza in patients with limited scleroderma and vulgar acne. Russian Journal of Skin and Sexually Transmitted Diseases, 2010, no. 6, pp. 8-10. (in Russ.).
16. Dvornikov A.S., Kruglova L.S., Minkina O.V. Photophoresis of Longidaza in patients with limited scleroderma. Physiology and pathology of immune system, 2007, vol. 11, no. 6: pp. 10-19. (in Russ.).
17. Makarova A.S. Experimental study of proteolytic prevention of excessive scarring in glaucoma surgery: Abstract of Med.Sc.D. Dissertation. Moscow, 2013. 24 p. (in Russ.).
18. Khodyreva L.A., Dudareva A.A., Karpov V.A Longidaza in combination therapy of chronic prostatitis. Effective pharmacotherapy. Urology and Nephrology, 2014; no. 3 (32): pp. 10-14. (in Russ.).
19. Shmyreva V.F., Ivanova A.S., Fedorov A.A. et al. Experimental research of enzyme preparation of Longidaza as means of prophylaxis excessive scarring after glaucoma surgery. All-Russian School of Ophthalmologist, 11th: abstract book, 2012, pp. 274-281. (in Russ.).
20. Shmyreva V.F., Ivanova A.S., Fedorov A.A. et al. Medico-biological study of Longidaza. Part 2. Glaucoma, 2012; no. 1, pp. 3-7. (in Russ.).
21. Vanshtein E.S., Zobina L.V. Physiotherapy in ophthalmology. In book Balneology and physiotherapy, 1985, pp. 566-590. (in Russ.).
22. Egorov V.V., Smoliakova G.P., Gohua T.I., Borisova Т.V. Magnetophoresis of cudesan in combination with derinat in treatment of purulent corneal ulcers. New technologies of diagnostics and treatment of eye diseases in the Far East: abstract book, 2012, pp. 184-187. (in Russ.).
23. Kamenskikh T.G., Raygorodsky Yu.M. Magnetotherapy and its combination with other physical factors. Oculist, 2004, no. 12, pp. 10-12. (in Russ.).
24. Skripkin Yu.K., Bogush P.G., Kruglova L.S., Dvornikov A.S. Experience in use of Longidaza by photophoresis in patients with limited scleroderma. Vestnik of Dermatology and Venereology, 2007, no. 5, pp. 57-59. (in Russ.).
25. Arestova N.N., Brzheskii V.V., Vakhova E.V., Yani E.V. Clinic, diagnosis and conservative therapy of bacterial corneal ulcers. Federal clinical guidelines, 2014. 16 p. (in Russ.).