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  •  Clinical case of insulinoma

    Редактор | 2022, Clinical case, Practical medicine part 20 №3. 2022 | 29 июля, 2022

    L.R. GAYSINA1, M.YU. NAZAROVA1, L.F. VOLKOVA2, A.A. ABAKUMOVA2

     1Kazan (Volga region) Federal University, Kazan

    2Healthcare unit of the Kazan (Volga region) Federal University, Kazan

     Contact details:

    Gaysina L.R. — PhD (medicine), Associate Professor of the Department of Internal Diseases

    Address:18 Kremlevskaya St., Kazan, Russian Federation, 420008, tel.: +7-903-307-92-47, e-mail: leilag@inbox.ru

     Insulinoma is a rather rare neuroendocrine tumor, its prevalence in the general population is approximately 1 case per 250,000–1,000 000 population. Insulinoma produces an excessive amount of insulin, causing episodes of hypoglycemia. Nonspecific complaints and difficulties of topical diagnosis can lead to a delay in diagnosis, which reduces the quality of life of patients. The path from the appearance of symptoms to the diagnosis in some cases takes many years. This article presents a clinical case of a young patient with insulinoma, describes the diagnostic search from the collection of anamnesis to laboratory and topical diagnostics, as well as treatment tactics. Taking into account the peculiarities of insulinoma course and diagnosis, endocrinologists and doctors of other clinical specialties should be alert about this disease.

    Key words: insulinoma, hypoglycemia, hyperinsulinism, neuroendocrine pancreatic tumor.

    REFERENCES

    1. Proekt klinicheskikh rekomendatsiy «Nediabeticheskie gipoglikemii» [Draft clinical guidelines «Non-diabetic hypoglycemia»], available at: https://www.endocrincentr.ru/sites/default/files/specialists/science/clinic-recomendations/nediabeticheskie_gipoglikemii_final_01.09.21
    2. Nikfarjam M., Warshaw A.L., Axelrod L., Deshpande V., Thayer S.P., Ferrone C.R., Castillo C.F.-d. Improved contemporary surgical management of insulinomas: a 25-year experience at the Massachusetts General Hospital. Ann Surg, 2008, vol. 247 (1), pp. 165–172.
    3. Cryer P.E., Axelrod L., Grossman A.B. et al. Evaluation and management of adult hypoglycemic disorders: an endocrine society clinical practice guideline. J Clin Endocrinol Metab, 2009, vol. 94 (3), pp. 709–728.
    4. The portal for rare diseases and orphan drugs website, available at: 4. https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GBHYPERLINK «https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=97279″&HYPERLINK «https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=97279″Expert=97279
    5. Tucker O.N., Crotty P.L., Conlon K.C. The management of insulinoma. Br J Surg., 2006, vol. 93, pp. 264–275.

    Метки: 2022, A.A. ABAKUMOVA, hyperinsulinism, hypoglycemia, insulinoma, L.F. VOLKOVA, L.R. GAYSINA, M.YU. NAZAROVA, neuroendocrine pancreatic tumor, Practical medicine part 20 №3. 2022

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