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  • Clinical case of diabetes mellitus comorbid with Gitelman syndrome

    Редактор | 2025, Clinical case, Practical medicine part 23 №5. 2025 | 14 октября, 2025

    A.O. POZDNYAK1, O.S. ELSUKOVA2

    1KSMA — branch campus of the FSBEI FPE RMACPE MOH Russia, Kazan

    2Kirov State Medical University, Kirov

    Contact details:

    Elsukova O.S. — PhD (Medicine), Associate Professor of the Department of Hospital Therapy

    Address: 112 Karl Marx St., 610027 Kirov, Russian Federation, tel.: +7-912-826-5112, e-mail: oselsukova@mail.ru

    The article describes a clinical case of diabetes mellitus with Gitelman syndrome in a 31-year-old woman. A brief overview of this form of tubulopathy is presented. The clinical significance for the endocrinologist and possible difficulties in managing such patients are highlighted.

    Key words: diabetes mellitus, Gitelman syndrome, secondary hyperaldosteronism.

    REFERENCES

    1. Baranov A.A., Namazova-Baranova L.S., Sergeeva T.V., Chumakova O.V., Paunova S.S., Zokirov N.Z. et al. Distal tubulopathies. Gitelman’s syndrome. Pediatricheskaya farmakologiya, 2019, no. 16 (2), pp. 144–148 (in Russ.).
    2. Schepkens H., Lameire N. Gitelman’s syndrome: an overlooked cause of chronic hypokalemia and hypomagnesemia in adults. Acta Clin. Belg, 2001, vol. 56 (4), pp. 248–254. DOI: 10.1179/acb.2001.036
    3. Blanchard A., Bockenhauer D., Bolignano D. et al. Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference. Kidney Int, 2017, vol. 91, pp. 24–33.
    4. Simon D.B., Nelson-Williams C., Bia M.J., Ellison D., Karet F.E., Molina A.M. et al. Gitelman’s variant of Bartter’s syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nature Genet, 1996, vol. 12, pp. 24–30.
    5. Nishihara G., Higashi H., Matsuo S. et al. Acute renal failure due to hypokalemic rhabdomyolysis in Gitelman’s syndrome. Clin. Nephrol, 1998, vol. 50 (5), pp. 330–332.
    6. Zverev Ya.F., Bryukhanov V.M., Lampatov V.V. Diseases and syndromes caused by genetic disorders of renal electrolyte transport. Nefrologiya, 2004, no. 8 (4), pp. 11–24 (in Russ.).
    7. Gitelman H.J., Graham J.B., Welt L.G. A new familial disorder characterized by hypokalemia and hypomagnesemia. Trans. Assoc. Am. Phys, 1966, vol. 79, pp. 221–235.
    8. Kardalas E., Paschou S.A., Anagnostis P., Muscogiuri G., Siasos G., Vryonidou A. Hypokalemia: a clinical update. Endocr. Connect, 2018, vol. 7, pp. R135–146.
    9. Fremont O.T., Chan J.C.M. Understanding Bartter syndrome and Gitelman syndrome. World J. Pediatr, 2012, vol. 8, pp. 25–30.
    10. Gjata M., Tase M., Gjata A., Gjergji Z. Gitelman’s syndrome (familial hypokalemia-hypomagnesemia). Hippokratia, 2007, vol. 11, pp. 150–153.

    Метки: 2025, A.O. POZDNYAK, diabetes mellitus, Gitelman syndrome, O.S. ELSUKOVA, Practical medicine part 23 №5. 2025, secondary hyperaldosteronism

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