N.V. Spiridonova, E.I. Basina

Samara State Medical University, 80 Polevaya St., Samara, Russian Federation, 443099  

Spiridonova N.V. ― D. Med. Sc., Professor, Head of the Department of Obstetrics and Gynecology of Institute of Postgraduate Education, tel. +7-903-309-66-33, e-mail: nvspiridonova@mail.ru

Basina E.I. ― postgraduate student of the Department of Obstetrics and Gynecology of Institute of Postgraduate Education, tel. +7-927-208-68-54, e-mail: basina83@inbox.ru 

The study included 92 patients of reproductive age with uterine cancer after conservative surgery ― conservative myomectomy and embolization of uterine arteries. For 34 of these patients the evaluation of the autoantibodies profiles content to TrM-03 was performed. The results were compared with the level of profiles of embryotropic autoantibodies to TrM-03 of 30 healthy women who were in the control group.

In patients with uterine leiomyoma, who had menometrorrhagia before treatment, was found decrease in the average content of the profiles of autoantibodies to platelet wall antigen TrM-03 as compared to the control group (р<0,001). Within 5 months after treatment the number of women suffering from uterine bleeding decreased by 6 times, the number of patients with concomitant symptoms ― by 3 times. 81.3% (p<0.001) of patients had normalization of profiles of autoantibodies to platelet antigen after conservative myomectomy, also 72.2% (p<0.001) of patients who underwent uterine artery embolization.

Key words: uterine leiomyoma, menometrorrhagia, uterine artery embolization, conservative myomectomy, autoantibodies.

REFERENCES

1. Sidorova I.S. Mioma matki (sovremennye aspekty etiologii, patogeneza, klassifikatsii i profilaktiki) [Uterine fibroids (modern aspects of the etiology, pathogenesis, classification and prevention)]. Moscow: MIA, 2002.

2. Buyanova S.N., Mgeliashvili M.V., Petrakova S.A. Current concepts of etiology and pathogenesis of the morphogenesis of uterine fibroids. Rossiyskiy vestnik akushera-ginekologa, 2006, no. 6, pp. 45-51 (in Russ.).

3. Samoylova T.E. Prospects for the use of analogues releasing hormone gonadotropin and antigestagens in the combined treatment of patients with uterine myoma. Akusherstvo i ginekologiya, 2006, pp. 34-40 (in Russ.).

4. Sidorova I.S., Sheshukova N.A., Zakoblukova S.V. The pathology of the endometrium in the presence of uterine fibroids. Ginekologiya, 2006, no. 4, pp. 57-60 (in Russ.).

5. Fonseca-Motinho J.A. et al. Abnormal uterine bleeding as a presenting symptom is related to multiple uterine leiomyoma: an ultrasound-based study. International Journal of Women’s Health, 2013, 5, pp. 689-694.

6. Tukhvatullina L.M., Antropova E.Yu. Adjuvant and alternative methods of treatment of patients with uterine myoma. Kazanskiy meditsinskiy zhurnal, 2007, vol. 88, no. 2 (in Russ.).

7. Poletaev A.B. Fiziologicheskaya immunologiya (estestvennye autoantitela i problemy nanomeditsiny) [Physiological Immunology (Natural autoantibodies and nanomedicine problems)]. Moscow: Miklosh, 2010. 219 p.

8. Spiridonova N.V., Basina E.I. Comparative evaluation of quality of life in patients with uterine myoma reproductive age after conservative myomectomy and uterine artery embolization. Izvestiya Samarskogo nauchnogo tsentra Rossiyskoy akademii nauk. Klinicheskaya meditsina, 2015, vol. 17, no. 2 (2), pp. 381-387 (in Russ.).

9. Tikhomirov A.L., Lubnin D.M. Mioma matki [Uterine fibroids]. Moscow: OOO “MIA”, 2006. P. 176.

10. Torry R.J., Rongish B.J. Angiogenesis in the uterus: potential regulation and relation to tumor angiogenesis. Amer. J. Reprod. Immunol, 1992, №27 (3-4), R. 171-179.

11. Rogozhina I.E., Khvorostukhina N.F. Influence of uterine artery embolization in the hemostatic system in patients with uterine myoma. Klinicheskaya meditsina, 2011, no. 3 (19), pp. 99-105 (in Russ.).

12. Rogozhina I.E. Modern understanding of the mechanisms of uterine bleeding in some urgent conditions in obstetrics and gynecology clinic. Saratovskiy nauchno-meditsinskiy zhurnal, 2011, vol. 7, no. 1, pp. 59-65 (in Russ.).

13. Aymagambetova G.N. Hemostasis study in patients with uterine myoma in conjunction with anemia. Vestnik NGU, 2007, vol. 5, no. 3, pp. 3-6 (in Russ.).