E.V. MIKHAILOVA, D.YU. LEVIN, D.V. KROSHKINA, I.G. EREMEEVA, A.A. SHULDYAKOV, YU.S. BUDARINA, E.S. PANKRATOVA, A.V. LEONOVICH, E.L. PEREVERZEV

Saratov State Medical University named after V.I. Razumovskiy, Saratov

Contact details:

Kroshkina D.V. — infectious disease doctor

Address: 112 Bolshaya Kazachya St., 410012 Saratov, Russian Federation, tel.: +7-927-620-42-34, e-mail: kroshkinadarina@mail.ru

In 2006, enterovirus infection began to be registered in federal statistics; since then, there has been a multidirectional dynamics of morbidity. In 2023, an outbreak of enterovirus infection occurred Saratov in region, which is the theme of this study. From June to September 2023, we analyzed the clinical and laboratory features of the enterovirus infection. We studied 280 medical records of patients hospitalized during this period. The patients were divided into two categories: the first group consisted of 175 children who swam in the Volga river and drank untreated water; the second group was 105 children with an established epidemiological factor (contact for enterovirus infection). The diagnosis was confirmed by detecting the virus RNA in cerebrospinal fluid, a smear from the oropharynx and 2 portions of feces using the polymerase chain reaction in real time. The data were statistically processed in Microsoft Excel. Fisher’s values were calculated for accuracy. Differences were considered statistically significant at the less than 0.05 level. During the outbreak, 850 patients were treated, including 723 cases of enterovirus meningitis (85%); other forms of enterovirus infection accounted for 127 cases (15%). The largest number of cases of enterovirus meningitis was noted in the cohort of preschool children (4–6 years). Boys fell ill significantly more often than girls: 67 and 33%, respectively. The main etiologic agent was the ECHO 30 virus.

Under the high water and air temperatures in Saratov region, enterovirus infection was actively spreading, reaching epidemic scale. During the active swimming season, water was a leading route in the infection transmission. Enterovirus meningitis, which accounted for 85% of cases, was the most common form of enterovirus infection and had a moderate severity in 95% of cases.

Key words: enterovirus infection, enterovirus meningitis, children.

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