Yu.A. TYURIN^1,2, I.D. RESHETNIKOVA^1,3, A.A. SHARIFULLINA¹, E.V. AGAFONOVA^1,2, R.S. FASSAKHOV³

¹Kazan Research Institute of Epidemiology and Microbiology under Rospotrebnadzor, 67 Bolshaya Krasnaya Str., Kazan, Russian Federation, 420015

²Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

³Kazan Federal University, 18 Kremlevskaya Str., Kazan, Russian Federation, 420008

 Tyurin Yu.A. — Cand. Med. Sc., Head of Research Laboratory of Immunology and Allergen Development, Assistant Lecturer of the Biochemistry Department, tel. (843) 238-99-79, e-mail: tyurin.yurii@yandex.ru

Reshetnikova I.D. — Cand. Med. Sc., Deputy Director for scientific and medical work, Associate Professor of the Department of Fundamentals of Clinical Medicine, tel. (843) 236-67-81, e-mail: reshira@mail.ru

Sharifullina A.A. — Cand. Med. Sc., allergologist-immunologist of the Specialized Polyclinic, tel. (843) 236-55-87, e-mail: alsusha74@mail.ru

Agafonova E.V. — Cand. Med. Sc., doctor for clinical laboratory diagnostic of Specialized Polyclinic, tel. (843) 299-42-05, e-mail: agafono@mail.ru

Fassakhov R.S. — Doc. Med. Sc., Professor of the Department of Fundamentals of Clinical Medicine, tel. (843) 296-19-28, e-mail: farrus@mail.ru

From immunological standpoint, the epithelium of the respiratory tract mucosa is the area of concentrated population of allergen-presenting cells that actively express the receptor group of the innate immune system. The article presents the results of examination of 44 patients with various forms of allergic rhinitis (AR). The characteristics of the cytokine profile of blood serum and nasal secretions, as well as local immunity parameters were studied. New data were obtained reflecting the characteristic cytokine profile in patients with year-round and seasonal forms of AR. It was established that in patients with year-round AR under sensitization to allergic components of Dermatophagoidespteronyssinus, activation of GM-CSF production remains. In patients with year-round form of AP with additional high sensitization to staphylococcal enterotoxins (SEs), a high profile of TNFα production and TSLP cytokine in nasal secretion is observed. In patients with the seasonal form of AR, the sensitization to allergic components of mold fungi is significantly increased. A high level was noted for them in the m3 component of Aspergillus fumigatus. Thus, the study clarifies some aspects of molecular immunopathogenesis of various forms of AR.

Key words: cytokines, allergic rhinitis, allergic components.

 (For citation: Tyurin Yu.A., Reshetnikova I.D., Sharifullina A.A., Agafonova E.V., Fassakhov R.S. Clinical and immunological features of patients with various forms of allergic rhinitis under sensitization by microbial, domestic and pollen allergens. Practical Medicine. 2018)

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