Clinical and immunological aspects of pregnancy and childbirth in pregnant women with influenza А (H1N1)
E.P. SHATUNOVA1, O.I. LINEVA1, D.M. KALIMATOVA2
1Samara State Medical University, Samara
2Russian National Research Medical University named after N.I. Pirogov, Moscow
Contact:
Shatunova E.P. ― MD, Professor of Department of Obstetrics and Gynecology
Address: 89 Chapaevskaya Str., 443099, Samara, Russian Federation, tel. (846) 207-19-68, e-mail: e.shatunova@mail.ru
The research objective was to evaluate the peculiarities of pregnancy, childbirth and newborn health in women who had H1N1 influenza during pregnancy, and to compare the data obtained with the level of vascular endothelial growth factor (VEGF).
Material and methods. 234 pregnant women in the gestation period from 26 to 38 weeks were divided into 2 groups: the main group of 128 pregnant women with influenza A (H1N1), the comparison group of 106 healthy pregnant women in the same gestation period without influenza. The features of pregnancy and childbirth, the state of the fetoplacental system, and markers of angiogenesis (VEGF) were studied.
Results. In pregnant women with influenza, complications of gestation, childbirth and the postpartum period, pathological conditions in newborns, morphological changes in the afterbirth and changes in VEGF were detected.
Conclusion. The results of a correlation study in women with highly pathogenic influenza showed a negative association of VEGF concentration with the frequency of the syndrome of delayed fetal development, anemia and the threat of premature birth, and polyhydramnion.
Key words: pregnancy, influenza, VEGF, placenta, newborns.
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