E.YU. YUPATOV, L.I. MALTSEVA

 Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan

Contact details:

Yupatov E.Yu. — MD, Associate Professor, Head of the Department of Obstetrics and Gynecology

Address: 36 Butlerov St., 420012 Kazan, Russian Federation, tel.: +7-917-873-87-21, e-mail: evguenii@yahoo.com

The purpose — to analyze 2024–2025 publications on the mutual effects of chronic venous diseases and pregnancy in order to formulate prospects for the problem further development.

Material and methods. The paper analyzes publications over the past 16 months concerning chronic venous diseases in pregnant women, including meta-analyses, reviews, and articles from PubMed and e-library sources.

Results. The analysis of the latest data from modern literature allows determining the prospects for studying the pathogenesis of obstetric and perinatal complications in pregnant women with chronic venous diseases. The approach to thromboprophylaxis in pregnant women might be revised, taking into account the role of endothelial dysfunction in the pathology of veins.

Conclusion. Currently, it is promising to search for new clinical and genetic markers for early prediction of obstetric pathology in pregnant women with endothelial dysfunction caused by venous insufficiency in order to timely correct the identified disorders and prevent adverse outcomes for mother and fetus.

Key words: chronic venous diseases, pregnancy, extragenital pathology, endothelial dysfunction.

REFERENCES

1. Kudryavtseva A.A., Aga A.D., Napalkov D.A., Zolotukhin I.A., Sokolova A.A. Venous thromboembolic complications in women with chronic venous diseases of the lower extremities receiving direct oral anticoagulants for atrial fibrillation. Flebologiya, 2024, vol. 18, no. 2, pp. 106–114 (in Russ.).
2. Avcı Işık S., Budak Ertürk E., Akay H.T., Karahan A., Akpınar D., Karslıoğlu A.O. Analysis of venous insufficiency risk factors and demographic characteristics among nurses: an analytical cross-sectional study. Medicina (Kaunas), 2024, vol. 60 (9), p. 1498. DOI: 10.3390/medicina60091498
3. Kola O., Huang Y., D’Alton M.E., Wright J.D., Friedman A.M. Trends in antepartum, delivery, and postpartum venous thromboembolism. Obstet. Gynecol, 2025, vol. 145 (3), pp. e98–e106. DOI: 10.1097/AOG.0000000000005818
4. Navti O.B., Pavord S. Venous thromboembolism in pregnant obese Individuals. Best Pract. Res. Clin. Obstet. Gynaecol, 2024, vol. 94, p. 102471. DOI: 10.1016/j.bpobgyn.2024.102471
5. He L., Liu J., Sun R., Qiu L., Tang L., Gao Y. Risk factors related to venous thromboembolism in pregnant women: a meta-analysis. Int. Angiol, 2024, vol. 43 (3), pp. 323–330. DOI: 10.23736/S0392-9590.24.05141-1
6. Shields L.E., Feldman D., Klein C., Foster M., Lin S. Venous thromboembolism prophylaxis should be recommended for antepartum admissions and cesarean delivery if age and body mass index are greater than 35. Am. J. Perinatol, 2025, vol. 42 (2), pp. 231–237. DOI: 10.1055/a-2342-0919
7. Kraus A.L., Rabe E., Kowall B., Schuldt K., Bock E., Stang A. et al. Differences in risk profile associated with varicose veins and chronic venous insufficiency — results from the Bonn Vein Study 1. Vasa, 2024, vol. 53 (2), pp. 145–154. DOI: 10.1024/0301-1526/a001115
8. Gavrilov K.A., Smetanina M.A., Korolenya V.A., Sevost’yanova K.S., Filipenko M.L., Shevela A.I. Molecular genetic aspects of varicose veins: modern concepts. Flebologiya, 2024, vol. 18 (1), pp. 48–53. DOI: 10.17116/flebo20241801148
9. Shirinbek O., Mnatsakanyan G.V., Odinokova S.N. Chronic venous diseases as a multidisciplinary problem: from a single pathogenesis to a systems approach. Vestnik Avitsenny, 2024, vol. 26, no. 1, pp. 117–132 (in Russ.). DOI: 10.25005/2074-0581-2024-26-1-117-132
10. Sánchez-Gil M.A., Fraile-Martinez O., García-Montero C., Toledo M.D.V., Guijarro L.G., De León-Luis J.A. et al. histopathological clues of enhanced inflammation in the placental tissue of women with chronic venous disease in lower limbs during pregnancy. J. Pers. Med, 2024, vol. 14 (1), p. 87. DOI: 10.3390/jpm14010087
11. Yupatov E.Yu., Mal’tseva L.I., Zefirova T.P. et al. Features of the expression of endothelial dysfunction markers in pregnant women with chronic venous diseases. Problemy reproduktsii, 2020, vol. 26, no. 3, pp. 92–99 (in Russ.). DOI: 10.17116/repro20202603192
12. Yupatov E.Yu. Kliniko-patogeneticheskoe znachenie nachal’nykh form khronicheskikh zabolevaniy ven v razvitii akusherskikh i perinatal’nykh oslozhneniy u beremennykh zhenshchin: avtoref. …dis. dokt. med. nauk [Clinical and pathogenetic significance of initial forms of chronic venous diseases in the development of obstetric and perinatal complications in pregnant women. Synopsis of dis. Dr med. sciences]. Meddok, 2024. 42 p.
13. Yupatov E.Yu. Morphological characteristics of the placenta structure in women in labor with early forms of chronic venous diseases. Vyatskiy meditsinskiy vestnik, 2023, vol. 3, no. 79, pp. 32–37 (in Russ.).
14. Zieliński A., Jasińska-Sumińska K., Bręborowicz A., Kowalska K., Zabel M., Wysocka T. et al. Changes of the serum properties and its effect on the endothelial cells restoration in patients with chronic venous disease treated with sulodexide. J. Vasc. Surg. Venous Lymphat. Disord, 2024, vol. 12 (5), p. 101941. DOI: 10.1016/j.jvsv.2024.101941
15. Pabon M.A., Weisbrod R.M., Castro C., Li H., Xia P., Kang J. et al. Venous endothelial cell transcriptomic profiling implicates METAP1 in preeclampsia. Circ. Res, 2025, vol. 136 (2), pp. 180–190. DOI: 10.1161/CIRCRESAHA.124.324606
16. Wu Y., Sun T., Medina P., Narasimhan P., Stevenson D.K., von Versen-Höynck F. et al. A novel stem cell model to study preeclampsia endothelial dysfunction. Reprod. Sci, 2024, vol. 31 (10), pp. 2993–3003. DOI: 10.1007/s43032-024-01590-z
17. Schulman S., Makatsariya A., Khizroeva J., Bitsadze V., Kapanadze D. the basic principles of pathophysiology of venous thrombosis. Int. J. Mol. Sci, 2024, vol. 25 (21), p. 11447. DOI: 10.3390/ijms252111447
18. Sidorova I.S., Managadze I.D. Modern concept of preeclampsia development: new data. Akusherstvo i ginekologiya, 2025, no. 2, pp. 5–13 (in Russ.). DOI: 10.18565/aig.2024.272
19. Gwozdzinski L., Pieniazek A., Gwozdzinski K. The roles of oxidative stress and red blood cells in the pathology of the varicose vein. Int. J. Mol. Sci, 2024, vol. 25 (24), p. 13400. DOI: 10.3390/ijms252413400
20. Fraile-Martinez O., García-Montero C., Pekarek T., Bujan J., Barrena-Blázquez S., Pena-Burgos E.M. et al. Dysregulation of circadian markers, HAT1 and associated epigenetic proteins, and the anti-aging protein KLOTHO in placenta of pregnant women with chronic venous disease. J. Pers. Med, 2025, vol. 15 (3), p. 107. DOI: 10.3390/jpm15030107
21. Fraile-Martinez O., García-Montero C., Gomez-Lahoz A.M., Sainz F., Bujan J., Barrena-Blázquez S. et al. Evidence of inflammatory network disruption in chronic venous disease: an analysis of circulating cytokines and chemokines. Biomedicines, 2025, vol. 13 (1), p. 150. DOI: 10.3390/biomedicines13010150
22. Viana-Mattioli S., Fonseca-Alaniz M.H., Pinheiro-de-Sousa I., Junior R.R., Mastella M.H., de Carvalho Cavalli R., Sandrim V.C. Plasma from hypertensive pregnancy patients induce endothelial dysfunction even under atheroprotective shear stress. Sci. Rep, 2025, vol. 15 (1), p. 4675. DOI: 10.1038/s41598-025-88902-8
23. Chung Ming C.L., Pienaar D., Ghorbanpour S., Chen H., Roberts L.M., Cole L. et al. 3D in vitro modelling of post-partum cardiovascular health reveals unique characteristics and signatures following hypertensive disorders in pregnancy. Biol. Sex Differ, 2024, vol. 15 (1), p. 94. DOI: 10.1186/s13293-024-00672-6
24. Selvakumar S.C., Preethi K.A., Sekar D. MicroRNA-510-3p regulated vascular dysfunction in preeclampsia by targeting vascular endothelial growth factor A (VEGFA) and its signaling axis. Placenta, 2024, vol. 153, pp. 31–52. DOI: 10.1016/j.placenta.2024.05.135
25. Xu X., Liu S., Gao Y., Cheng L. Epigallocatechin gallate (EGCG) alleviates inflammation and endothelial dysfunction and improves pregnancy outcomes in preeclampsia (PE)-like rats via eNOS/Nrf2/HO-1 pathway. J. Reprod. Immunol, 2024, vol. 164, pp. 104263. DOI: 10.1016/j.jri.2024.104263
26. Shi M., Sun L., Wei J., Shen Y., Wang J., Zhang P. et al. Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding. Commun. Biol, 2025, vol. 8 (1), p. 90. DOI: 10.1038/s42003-025-07547-5
27. Yupatov E.Yu. Assessment of the functional state of the veins of the lower extremities and expression of a marker of endothelial dysfunction in pregnant women with CVD against the background of the use of an endothelioprotector. Zhenskaya klinika, 2023, no. 2, pp. 26–31 (in Russ.).