A.A. YAKUPOVA¹, T.V. NIKISHOVA², E.A. BUSURGINA³, L.A. KHALITOVA³

¹Kazan State Medical University, Kazan

²Kazan State Medical Academy, Kazan

³City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan

 Contact details:

Yakupova A.A. — MD, Associate Professor of the Department of Neurology

Address: 49 Butlerova St., Kazan, Russian Federation, 420012, tel.: +7-917-390-92-04, e-mail: aidayakupova@yandex.ru

 The purpose — to study the characteristics of polysynaptic reflex excitability of the brain stem based on an electroneuromyographic research of the blink reflex in patients with exogenous constitutional obesity (ECO).

Material and methods. 288 women (mean age 37.5 (2.8) years) with ECO and 45 healthy women of the same age group were examined. All patients underwent a clinical and anthropometric examination, including quantitative indicators of body size and weight and electroneuromyographic study of the blink reflex (BR).

Results. The anthropometric study revealed the presence of two variants of fat deposition topography — android (AT) and gynoid (GT) types. The ratio of ECO-AT and ECO-GT in this sample was 41.28% and 58.72%, respectively. Patients with ECO-GT showed a significant increase in the duration of the R2 component of the BR (44.1 (1.5) ms) (p <0.01), a reduction in its latency (35.5 (0.8) ms) (p < 0.05) and a decrease in the threshold (1.9 (0.1) mA) (p < 0.01) compared to the indicators of healthy subjects. A direct significant correlation was found between the level of polysynaptic reflex excitability and the level of obesity (r = 0.75, p < 0.05). The data obtained characterize the role of a lack of inhibition processes in the central nervous system and a functional deficit of the sensorimotor component in the ECO development mechanisms, with a disorder of autonomic nervous system and behavioural and emotional disorders, including eating behavior. As the degree of obesity increases, as well as with a more unfavorable pathogenetic type of ECO, the severity of changes in polysynaptic reflex excitability of the brain stem also increases.

Conclusions. The study of polysynaptic reflex excitability of the brain stem by electroneuromyographic BR testing shows the role of dysfunction of the CNS suprasegmental parts in the ECO development and progression.

Key words: exogenous constitutional obesity, polysynaptic reflex excitability, blink reflex.

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