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  • Changes in haemostatic system in patients with inflammatory bowel disease

    Редактор | 2014, Practical medicine 04 (14) Innovative technologies in medicine. Part 1 | 30 июля, 2014

    A.K. RAMAZANOVA1, 2, D.I. ABDULGANIEVA2, I.G. MUSTAFIN2, A.K. ODINTSOVA1, B.R. RAMAZANOV2

    1Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation 420012

    2Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan, 138 Orenburgskiy Trakt, Kazan, Russian Federation 420064

    Ramazanova A.Kh. — physician of the Department of Gastroenterology, postgraduate student of the Department of Biochemistry, tel. +7-927-404-74-40,

    e-mail: alsuramazan@mail.ru1,2

    Abdulganieva D.I. — D. Med. Sc., Head of the Department of Hospital Therapy, tel. +7-987-296-27-68, e-mail: diana_s@mail.ru2

    Mustafin I.G. — D. Med. Sc., Professor, Head of the Department of Biochemistry, tel. (843) 236-68-82, e-mail: ilshat64@mail.ru2

    Odintsova A.K. — Cand. Med. Sc., Head of the Department of Gastroenterology, tel. +7-987-290-53-44, e-mail: odincovaa@yandex.ru1

    Ramazanov B.R. — postgraduate student of the Department of Pathophysiology, tel. +7-927-244-29-66, e-mail: bulatramazan@mail.ru2

    The article presents the study of changes in the haemostatic system in patients with exacerbation of inflammatory bowel disease. The spatial dynamics of blood plasma coagulation in patients with Crohn’s disease and ulcerative colitis was studied. The results showed that patients with Crohn’s disease tend to have more pronounced hypercoagulable disorders of haemostasis.

    Key words: inflammatory bowel disease, thromboembolic complications, spatial dynamics of blood plasma coagulation, hypercoagulability.

     

     

    REFERENCES

    1. Freeman H.J. Venous thromboembolism with inflammatory bowel disease. World J. Gastroenterol., 2008, vol. 14, no. 7, pp. 991-993.

    2. Scaldaferri F., Lancellotti S., Pizzoferrato M., De Cristofaro R. Haemostatic system in inflammatory bowel diseases: new players in gut inflammation. World J. Gastroenterol, 2011, vol. 17, pp. 594-608.

    3. Owczarek D., Cibor D., Głowacki M. et al. Inflammatory bowel disease: epidemiolo-gy, pathology and risk factors for hypercoagulability. World J. Gastroenterol., 2014, vol. 20, no. 1, pp. 33-63.

    4. Jackson L.M., O’Gorman P.J., O’Connell J. et al. Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. Q.J.M., 1997, vol. 9, pp. 183-188.

    5. Ivashkin V.T., Shelygin Yu.A., Abdulganieva D.I. et al. Draft clinical guidelines for the diagnosis and treatment of adult patients with Crohn’s disease. Koloproktologiya, 2013, no. 3, pp. 3-34 (in Russ.).

    6. Lewis J.D., Chuai S., Nessel L. et al. Use of the Non-invasive Components of the Mayo Score to Assess Clinical Response in Ulcerative Colitis. Inflamm. Bowel Dis., 2008, vol. 14, no. 12, pp. 1660-1666.

    7. Best W.R., Becktel J.M., Singleton J.W. Rederived values of the eight coefficients of the Crohn’s disease activity index (CDAI). Gastroenterology, 1979, vol. 77, pp. 843-846.

    Метки: A.K. ODINTSOVA, A.K. RAMAZANOVA, B.R. RAMAZANOV, D.I. ABDULGANIEVA, hypercoagulability, I.G. MUSTAFIN, inflammatory bowel disease, Practical medicine 04 (14) Innovative technologies in medicine. Part 1, spatial dynamics of blood plasma coagulation, thromboembolic complications

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