N.V. KORNEVA, А.А. STARSHINOVA, YU.E. OVCHINNIKOVA, Е.I. POTAPENKO, О.А. YAKUNOVA, I.PH. DOVGALYUK

St. Petersburg Scientific and Research Institute of Phthisiopneumology of the Ministry of Health of the Russian Federation

Starshinova Anna Andreevna
Candidate of Medical Science, Head of Phthisiopulmonology Department
2-4 Ligovsky avenue, Saint Petersburg 191036
tel. 8-905-204-38-61, e-mail: starshinova_777@mail.ru

The article presents the results of a survey of 152 children aged 3 to 14 years with the proven case of respiratory tuberculosis in order to compare the immunological parameters at different activity of a specific process. In accordance with the results of the Quantiferon test patients were divided into two groups: I group (33) ― patients with negative results, II group (119) ― with positive results. A comparative analysis of the complex of immunological methods in groups was performed. It has been established that the most informative for the evaluation of the activity of a specific process is a complex of immunological methods, including DIASKINTEST®, conditioned hemolysis test, detection of the level of proinflammatory cytokines IL-2 and TNF-α and antibodies and antimicobacterial antibodies of class Ig М and Ig G according to anda-tb ELISA.

Key words: children, diagnostics, DIASKINTEST®, immunity, Quantiferon test, tuberculosis. 

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