Change of immunological parameters in children with different specific process activity
N.V. KORNEVA, А.А. STARSHINOVA, YU.E. OVCHINNIKOVA, Е.I. POTAPENKO, О.А. YAKUNOVA, I.PH. DOVGALYUK
St. Petersburg Scientific and Research Institute of Phthisiopneumology of the Ministry of Health of the Russian Federation
Starshinova Anna Andreevna
Candidate of Medical Science, Head of Phthisiopulmonology Department
2-4 Ligovsky avenue, Saint Petersburg 191036
tel. 8-905-204-38-61, e-mail: starshinova_777@mail.ru
The article presents the results of a survey of 152 children aged 3 to 14 years with the proven case of respiratory tuberculosis in order to compare the immunological parameters at different activity of a specific process. In accordance with the results of the Quantiferon test patients were divided into two groups: I group (33) ― patients with negative results, II group (119) ― with positive results. A comparative analysis of the complex of immunological methods in groups was performed. It has been established that the most informative for the evaluation of the activity of a specific process is a complex of immunological methods, including DIASKINTEST®, conditioned hemolysis test, detection of the level of proinflammatory cytokines IL-2 and TNF-α and antibodies and antimicobacterial antibodies of class Ig М and Ig G according to anda-tb ELISA.
Key words: children, diagnostics, DIASKINTEST®, immunity, Quantiferon test, tuberculosis.
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