P.V. LYSKIN, V.D. ZAKHAROV, M.I. ZGOBA

The S. Fyodorov Eye Microsurgery Federal State Institution, 59A Beskudnikovsky blvd, Moscow, Russian Federation, 127486

 Lyskin P.V. ― Cand. Med. Sc., ophthalmo-surgeon of the Department of Vitreoretinal Surgery and Eye Diabetes, tel. (499) 488-89-26, e-mail: plyskin@yahoo.com

Zakharov V.D. ― D. Med. Sc., Professor, Head of the Department of Vitreoretinal Surgery and Eye Diabetes, tel. (499) 488-85-53, e-mail: fgu@mntk.ru

Zgoba M.I. ― postgraduate student of the Department of Vitreoretinal Surgery and Eye Diabetes, e-mail: zgobami@gmail.com

 The article presents the analysis of the dynamics and increase of concentration of proinflammatory cytokines in blood serum after vitreoretinal surgical procedures in 78 patients operated for rhegmatogenous retinal detachment employing endophotocoagulation (EPC). The patients were divided into three groups according to the total laser energy during the intraoperational (EPC) of the retina. The degree of inflammatory reaction was assessed by the change in the concentration of interleukin-1β (IL-1β), interleukin-8 (IL-8), interleukin-6 (IL-6) and C-reactive protein (CRP) in blood serum. The greatest increase in the concentration of inflammatory markers – IL-1β, IL-8 and CRP ― was registered in the group with intraoperative photocoagulation of 3-4 rows or more, which corresponded to 986±178 coagulates and total laser energy of 451.9±126.2 J. The increase in IL-6 concentration was registered regardless of the volume of photocoagulation. A relationship was revealed between the total energy of photocoagulation and the increase in the concentrations of CRP, IL-1β, IL-8 in the blood after endovitreal surgery of retinal detachment. The intraoperative burn component of photocoagulation, more than 986±178 coagulates, with the total laser power Q=451.9±126.2 J, which corresponds to photocoagulation in 3-4 rows, is one of the risk factors for the inflammatory-proliferative reaction in the postoperative period.

Key words: inflammation, rhegmatogenous retinal detachment, endophotocoagulation, C-reactive protein, interleukin-8, interleukin-1β, interleukin-6.

REFERENCES

1. Kolechenkova I.V. Modern views on the pathogenesis of uveitis. Rossiyskaya detskaya oftal’mologiya, 2014, no. 4, p. 42 (in Russ.).
2. Metelitsyna I.P., Levitskaya G.V., Gaffari Sakhbi Ben Mokhamed Monsef. Cytokine blood profile in patients with rheumatogenic retinal detachment with a different clinical picture. Ukrains’kiy medichniy al’manakh, 2011, vol. 14, no. 3, pp. 119-121 (in Russ.).
3. Tikhonovich M.V., Lyskin P.V., Ioyleva E.E. et al. Expression of growth, trophic and proinflammatory factors in the epiretinal membranes of patients with severe proliferative vitreoretinopathy. Oftal’mokhirurgiya, 2015, 4, pp. 36-42 (in Russ.).
4. Khodzhaev N.S., Chernykh V.V., Kuntysheva K.E. Clinico-pathogenetic and prognostic significance of the factors of the progression of diabetic retinopathy against the background of hypertonic disease after phacoemulsification. Oftal’mokhirurgiya, 2015, 3, pp. 37-42 (in Russ.).
5. Chernykh D.V., Smirnov E.V., Gorbenko O.M. et al. Disturbances of cytokine regulation in the pathogenesis of proliferative diabetic retinopathy. Oftal’mokhirurgiya, 2015, 2, pp. 50-54 (in Russ.).
6. Shaimova V.A. The role of proinflammatory cytokines in eye diseases (review of literature). Oftal’mokhirurgiya i terapiya, 2004, vol. 4, no. 3, pp. 30-32.
7. Heo M.S., Kim H.W., Lee J.E. et al. The clinical features of macular pucker formation after pars planavitrectomy for primary rhegmatogenous retinal detachment repair. Korean J. Ophthalmol, 2012, Oct, 26 (5), pp. 355-61.
8. Kiss C.G., Richter-Müksch S. et al. Anatomy and function of the macula after surgery for retinal detachment complicated by proliferative vitreoretinopathy. American Journal of Ophthalmology, 2007 Dec, 144 (6), pp. 872-877.
9. Kunikata H., Abe T., Nishida K. Successful outcomes of 25- and 23-gauge vitrectomies for giant retinal tear detachments. Ophthalmic. Surg. Lasers Imaging, 2011, Nov-Dec, 42 (6), pp. 487-92.
10. Martínez-Castillo V., Boixadera A., Distéfano L. et al. Epiretinal membrane after pars planavitrectomy for primary pseudophakic or aphakicrhegmatogenous retinal detachment: incidence and outcomes. Retina, 2012, Jul, 32 (7), pp. 1350-5.
11. Silva D.J., Kwan A., Bunce C., Bainbridge J. Predicting visual outcome following retinectomy for retinal detachment. British Journal of Ophthalmology, 2008, Jul, 92 (7), pp. 954-8.
12. Paulus Y.M., Kuo C.H., Morohoshi K. et al. Serum inflammatory markers after rupture retinal laser injury in mice. Ophthalmic. Surg. Lasers Imaging Retina, 2015, Mar, 46 (3), pp. 362-8.
13. Poya Tababat-Khani, Lisa M. Berglund, Carl-David Agardh et al. Photocoagulation of Human Retinal Pigment Epithelial Cells In Vitro: Evaluation of Necrosis, Apoptosis, Cell Migration, Cell Proliferation and Expression of Tissue Repairing and Cytoprotective Genes. PLoS One, 2013, 8 (8), p. e70465.
14. Khoroshilova ― Maslova I.P., Leparskaya N.L., Nabieva M.K., Andreeva L.D. Development of a pathogenetically grounded standard experimental model of proliferative vitreoretinopathy induced by cytokines. Rossiyskiy oftal’mologicheskiy zhurnal, 2013, vol. 6, no. 1, pp. 78-80 (in Russ.).
15. Dehne M.G., Sablotzki A., Hoffmann A. et al. Alterations of acute phase reaction and cytokine production in patients following severe burn injury. Burns, 2002, 28 (6), pp. 535-542.