Cerebrovascular reactivity in patients with ischemic stroke with various severity of motor deficit
R.M. SAIKHUNOV1, 2, T.V. DANILOVA1, 2
1Kazan State Medical University, Kazan
2Interregional Clinical and Diagnostic Center, Kazan
Contact details:
Saikhunov R.M. — post-graduate student of the Department of Neurology
Address: 49 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7 (843) 236-06-52, e-mail: rustamsaih@mail.ru
The purpose — to examine a link between cerebrovascular reactivity and the severity of motor deficits in patients experiencing the first ischemic stroke.
Material and methods. The authors present the results of a comprehensive examination of 113 patients during the acute phase of their first diagnosed ischemic stroke. All patients underwent muscle strength assessment and cerebrovascular reactivity evaluation as part of the complex examination.
Results. Five groups were identified based on the severity of paresis (scores 4 to 0). The reduction in muscle strength in each group significantly corresponded to a more pronounced decrease in cerebrovascular reactivity. However, there was no significant relationship between the degree of cerebral vessel stenosis and reactivity indicators.
Conclusion. The degree of disruption in regulatory mechanisms of cerebral circulation is related to the severity of paresis. Assessing cerebral vascular reactivity during the acute phase of ischemic stroke has diagnostic value, and further studies are needed to understand its role in functional recovery.
Key words: movement disorders, paresis, ischemic stroke, cerebrovascular reactivity.
REFERENCES
- Arkhincheeva N.Ts., Bal’khaev I.M., Kasimova V.N. Complex rehabilitation of post-stroke motor disorders of hand function (clinical case). Nauka molodykh (Eruditio Juvenium), 2024, vol. 12, no. 1, pp. 111–120 (in Russ.). DOI: 10.23888/HMJ2024121111-120
- Kuzina O.L., Kulesh A.A., Shestakov V.V. Cerebral vasomotor reactivity in patients in the acute period of ischemic stroke. Permskiy meditsinskiy zhurnal, 2015, vol. 32, no. 6, pp. 25–30 (in Russ.).
- Sumin A.N., Kolmykova Yu.A., Kukhareva I.N. et al. Clinical significance of pathological ankle-brachial index in patients with acute cerebrovascular accident. Nevrologicheskiy zhurnal, 2016, no. 3, pp. 158–164 (in Russ.). DOI: 10.18821/1560-9545-2016-21-3-158-164
- Sforza M., Bianchini E., Alivernini D. et al. The impact of cerebral vasomotor reactivity on cerebrovascular diseases and cognitive impairment. J. Neural Transmission,2022, vol. 129 (11), pp. 1321–1330. DOI: 10.1007/s00702-022-02546-w
- Rune Aaslid. Cerebral autoregulation and vasomotor reactivity. Front. Neurol. Neurosci, 2006, vol. 21, pp. 216–228. DOI: 10.1159/000092434
- Krishnamurthy V., Sprick J.D., Krishnamurthy L.C. et al. The utility of cerebrovascular reactivity MRI in brain rehabilitation: a mechanistic perspective. Front. Physiology, 2021, vol. 12, pp. 1–14. DOI: 10.3389/fphys.2021.642850
- Nikitina Yu.M., Trukhanova A.I. Ul’trazvukovaya dopplerovskaya diagnostika v klinike [Ultrasound Doppler diagnostics in the clinic]. Moscow: Izd-vo MIK, 2004. Pp. 176–189.
- Shevchik A.G. Cerebral hemodynamics in patients in the acute period of hemispheric ischemic stroke according to transcranial Doppler sonography. Meditsinskiy al’manakh, 2008, no. 4, pp. 142–143 (in Russ.).
- Adams H.P.Jr., Bendixen B.H., Kappelle L.J. et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke, 1993, vol. 24, pp. 35–41. DOI: 10.1161/01.STR.24.1.35
- Gaydar B.V., Parfenov V.E., Svistov D.E. Otsenka reaktivnosti mozgovogo krovotoka s primeneniem ul’trazvukovykh metodov diagnostiki. Ul’trazvukovaya dopplerovskaya diagnostika sosudistykh zabolevaniy [Assessment of cerebral blood flow reactivity using ultrasound diagnostic methods. Ultrasound Doppler diagnostics of vascular diseases]. Moscow: Vidar, 1998. Pp. 241–248.
- Bustanov O.Ya., Khaydarova S.R., Rakhmatullaev F.A. Cognitive and motor disorders against the background of cerebral vascular atherosclerosis. Ekonomika i sotsium, 2023, pp. 201–204 (in Russ.).
- Gur A.Y., Gücüyener D., Korczyn A.D. et al. Cerebral vasomotor reactivity and dementia after ischemic stroke. Acta Neurol. Scand, 2010, vol. 122, pp. 383–388. DOI: 10.1111/j.1600-0404.2010.01323.x
- Tomoto T., Tarumi T., Chen J. et al. Cerebral vasomotor reactivity in amnestic mild cognitive impairment. Alzheimers Dis, 2020, vol. 77 (1), pp. 191–202. DOI: 10.3233/JAD-200194
- Ivey F.M., Ryan A.S., Hafer-Macko Ch.E. et al. Improved cerebral vasomotor reactivity after exercise training in hemiparetic stroke survivors. Stroke, 2011, vol. 42 (7), pp. 1994–2000. DOI: 10.1161/STROKEAHA.110.607879