G.A. MUKHETDINOVA¹, G.D. BORIS², R.M. FAZLYEVA¹, G.Kh. MIRSAEVA¹, E.R. KAMAEVA¹, A.A. TALKHINA²

¹Bashkir State Medical University, Ufa, Russian Federation

²City Clinical Hospital №5, 93 Parkhomenko Str., Ufa, Russian Federation, 450005

  Contact details:

Mukhetdinova G.A. ― D. Sc. (medicine), Professor of the Faculty Therapy Department

Address: 3 Lenin Str., Ufa, Russian Federation, 450008, e-mail: gmukhetdinova@yandex.ru

Research objective ― to study the relationship of the functional state of the kidneys and arterial hypertension in convalescents of hemorrhagic fever with renal syndrome (HFRS).

Material and methods. Convalescents of HFRS, aged 18 to 50 years, observed at 3, 6, and 12 months after the disease. There were 2 groups: 1 group ― convalescents without arterial hypertension (AH): 44 patients, 2 group ― convalescents with AH: 40 patients. The glomerular filtration rate (GFR) for creatinine and cystatin C, albuminuria, blood pressure level depending on risk factors and kidney function were measured.

Results. In HFRS convalescents, blood pressure correlated with such factors as age, hyperglycemia, body mass index and hypercholesterolemia. The level of GFR normalized only 6 months after the disease, albuminuria persisted for an even longer period of time. One year after the disease, the moderate and high combined risk of cardiovascular events and prognosis of chronic kidney disease (CKD) was determined in 21.4% and 4.8% of patients, respectively.

Conclusion. Cystatin C makes it possible to predict the formation of CKD earlier than creatinine. Our results showed the need for follow-up observation of convalescents, correction of risk factors and prescription of nephroprotective therapy according to indications.

Key words: arterial hypertension, chronic kidney disease, cystatin C, dispensary observation, hemorrhagic fever with renal syndrome.

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