L.M. SHARAPHETDINOVА¹, A.M. MAZITOVA¹, O.A. KRAVTSOVA¹, L.I. MALTSEVA², E.Yu. YUPATOV²

¹Kazan (Volga region) Federal University, 18 Kremlevskaya St., Kazan, Russian Federation, 420008

²Kazan State Medical Academy, 36 Butlerov St., Kazan, Russian Federation, 420043

Sharaphetdinova L.M. — postgraduate student of the Department of Biochemistry and Biotechnology, tel. (843) 233-78-31, e-mail: l_sungatullina@mail.ru

Mazitova A.M. — student of the Department of Biochemistry and Biotechnology, tel. (843) 233-78-31, e-mail: sashamazitova@mail.ru

Kravtsova O.A. — Cand. Biol. Sc., Associate Professor of the Department of Biochemistry and Biotechnology, tel. (843) 233-78-31, e-mail: okravz@yandex.ru

Maltseva L.I. — D. Med. Sc., Professor, Head of the Department of Obstetrics and Gynecology № 1, tel. +7-905-314-40-51, e-mail: laramalc@mail.ru

Yupatov E.Yu. — Cand. Med. Sc., Associate Professor of the Department of Obstetrics and Gynecology № 1, tel. +7-917-873-87-21, e-mail: evguenii@yahoo.com

The article presents the results of the assessment of the impact of inflammatory cytokine gene polymorphisms IL1β (rs1143634), IL6 (rs1800795) and TNF-α (rs1800629) on the formation of hereditary predisposition to the development of pre-eclampsia in women of the Republic of Tatarstan. There were studied 210 patients, of which 140 were with uncomplicated pregnancy, and 70 had signs of pre-eclampsia. When assessing the level of proinflammatory cytokines IL1β, IL and TNF-α the groups studied had no statistically significant differences, in addition, these indicators had normal values. When analyzing the contribution of polymorphism of genes, encoding investigated cytokines, to genetic predisposition to preeclampsia, it was found that women with heterozygous genotype at a polymorphic locus of the gene TNF-α have an increased risk of pregnancy complications (OR=1,9118; 95%CI at 1.2446-2,9366), while the rest of the investigated loci had no statistically significant differences.

Key words: preeclampsia, proinflammatory cytokines, polymorphism of genes.

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