E.M. KAMENSKIKH, M.A. TITOVA, V.M. ALIFIROVA, N.F. MUSINA, T.N. NIKOLAEVA

 Siberian State Medical University, Tomsk

Contact details:

Kamenskikh E.M. — post-graduate student of the Department of Neurology and Neurosurgery

Address: 2 Moskovsky trakt, Tomsk, Russian Federation, 634050, tel.: +7-953-913-50-93, e-mail: kamenskih.em@ssmu.ru

 The relationship was studied between the rs10492972 polymorphism of the KIF1B gene and the risk of multiple sclerosis (MS), clinical phenotype of disease and response to disease modifying drugs (DMD) treatment in the patient’s population of Tomsk region. The study group included 152 patients; the control group consisted of 689 healthy volunteers. The results showed the impact of the risk allele C of KIF1B (rs10492972) gene polymorphism on the progressive forms of MS development (especially on primary progressive MS), and the relationship of the T allele with an early onset and relapsing-remitting course. The risk allele C also showed an association with the lack of response to second-line DMD therapy. The results of our study confirmed the association of the KIF1B (rs10492972) gene’s allele C with an unfavorable course of MS.

Key words: multiple sclerosis, polymorphisms, gene, alleles, KIF1B.

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