F.S. BOVA¹, O.I. KIT², A.Yu. MAKSIMOV², S.N. DIMITRIADI²

¹Center for Urology, Nephrology and Hemodialysis of the Regional Hospital N 2, 33 Pervoy Konnoy Armii Str., 344112 Rostov-on-Don, Russian Federation

²Rostov Scientific-Research Oncology Institute, 63 14^th Liniya Str., 344037 Rostov-on-Don, Russian Federation

 Bova Filipp Sergeyevich – Cand. Med. Sc., Head of the Center for Urology, Nephrology and Hemodialysis, tel.: +7 (863)254-98-90; e-mail: alald@inbox.ru

  The article presents the results of prognostic significance evaluation of the connection between the presence of high-grade prostatic intraepithelial neoplasia (PIN2) surrounded by adenocarcinoma and the recurrence of localized prostate cancer (РС) after radical prostatectomy (RPЕ) in two years after operation. The results of examination of 176 patients with localized prostate cancer at clinical stage T1c-T2cN0M0, operated with RPE, were studied. With the presence of PIN2 in peritumoral zone in operating biopsies in patients with prostate cancer, the frequency of biochemical recurrence (26 %) and histologically verified relapse (24 %) is higher than in patients with PC without signs of neoplasia in the prostate (12.5 % ​​and 7.5 %, respectively). The prognostic significance of the presence of PIN2 in peritumoral zone in operating biopsies in patients with localized prostate cancer, in relation to the risk assessment of recurrence in two years after surgery, increases in combination with a shortened interval of biochemical recurrence (12 months or less): the relative risk of relapse 13.0 (р = 0.05), the diagnostic sensitivity 95.2 %, the diagnostic specificity 100 %.

Key words: prostate cancer, prostatic intraepithelial neoplasia of high degree, relapse, prognosis.

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