A.V. GANEEVA¹, P.L. KAPELYUSHNIK¹, E.V. VALEEVA¹, E.R. GILMANSHIN¹, A.D. KHAIRULLINA¹, G.M. KURBANOVA²

 ¹Kazan State Medical University, Kazan

²City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan

Contact details:

Ganeeva A.V. — PhD (Medicine), Associate Professor of the Department of Obstetrics and Gynecology named after Prof. V.S. Gruzdev

Address: 49 Butlerov St., 420012 Kazan, Russian Federation, tel.: +7-917-253-15-78, e-mail: a.v.ganeeva@gmail.com

Preeclampsia is a pregnancy complication characterized by a violation of the maternal immune tolerance towards the fetus. CXCR2 is one of the genes regulating the immune response system: it encodes the interleukin-8 β-receptor. The rs1126579 polymorphism of the CXCR2 gene is associated with a predisposition to a number of somatic diseases, but data on its role in obstetric pathology is limited.

The purpose to assess the relationship between the rs1126579 polymorphism of CXCR2 gene and the development of preeclampsia in women living in the Republic of Tatarstan.

Material and methods. The study included 318 pregnant women: the main group consisted of 119 participants with preeclampsia and the control group consisted of 199 patients without hypertensive disorders. The molecular genetic analysis included the isolation of DNA from whole blood, followed by genotyping of the rs1126579 polymorphism of the CXCR2 gene.

Results. Analysis of the distribution of alleles and genotypes of the rs1126579 polymorphism of the CXCR2 gene did not reveal significant differences between the groups (p > 0.05).

Conclusions. The rs1126579 polymorphism of CXCR2 gene is not associated with the development of preeclampsia in women living in the Republic of Tatarstan.

Key words: preeclampsia, rs1126579 polymorphism of CXCR2 gene, IL-8

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