G.M. SHARAFUTDINOVA, F.A. KHABIROV, T.I. KHAIBULLIN, D.I. MARAPOV, S.A. BELOV

 KSMA-Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan

 Contact details:

Sharafutdinova G.M. — PhD (medicine), Associate Professor of the Department of Neurology

Address: 36 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7 (843) 233-34-91, e-mail: guzel29@mail.ru

The article shows the results of studying the factors influencing mortality in multiple sclerosis. The following risk factors for death were established: male gender, rural population, primary progressive and secondary progressive type of multiple sclerosis, high initial EDSS indicators at the disease onset (4 points and higher), disability group 1, later age of the disease onset, a long period from the disease onset to inclusion in the register. Disability indicated a 1.78-fold increase in the chances of death.

Key words: multiple sclerosis, mortality, risk factors, EDSS, disability.

REFERENCES

1. Akhmedova G.M., Marapov D.I., Khabirov F.A., Khaybullin T.I. Svidetel’stvo o gosudarstvennoy registratsii bazy dannykh no. 2023621925 RF. Baza dannykh dlya opredeleniya faktorov riska neblagopriyatnykh iskhodov pri rasseyannom skleroze: no. 2023620717: zayavl. 20.03.2023: opubl. 09.06.2023; zayavitel’ Federal’noe gosudarstvennoe byudzhetnoe obrazovatel’noe uchrezhdenie dopolnitel’nogo professional’nogo obrazovaniya “Rossiyskaya meditsinskaya akademiya nepreryvnogo professional’nogo obrazovaniya” MZ RF [Certificate of state registration of the database No. 2023621925 of the Russian Federation. Database for determining risk factors for adverse outcomes in multiple sclerosis: No. 2023620717: declared 20.03.2023: published 09.06.2023; applicant Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuous Professional Education» of the Ministry of Health of the Russian Federation]. EDN DBHGBI.
2. Boynova I.V., Samarina D.V., Katorova A.V., Tokareva N.G. Clinical and epidemiological features of multiple sclerosis in the Russian Federation. Sovremennye problemy nauki i obrazovaniya, 2022, no. 5 (in Russ.), available at: https://science-education.ru/ru/article/view?id=32006 (accessed on: 04.08.2024).
3. Suslina Z.A., Zakharova M.N., Zavalishin I.A., Boyko A.N. et al. Protocol for the management of patients with multiple sclerosis. Problemy standartizatsii v zdravookhranenii, 2006, no. 2 (in Russ.), available at: https://cyberleninka.ru/article/n/protokol-vedeniya-bolnyh-rasseyannyy-skleroz (accessed on: 04.08.2024).
4. Yang, Y., Du, Z., Liu, Y. et al. Disability and the risk of subsequent mortality in elderly: a 12-year longitudinal population-based study. BMC Geriatr, 2021, vol. 21 (1), p. 662. DOI: 10.1186/s12877-021-02611-1
5. Hirst C., Swingler R., Compston D. et al. Survival and cause of death in multiple sclerosis: a prospective population-based study. J. Neurol. Neurosurg. Psychiatry, 2008, vol. 79 (9), pp. 1016–1021. DOI: 10.1136/jnnp.2007.127332