L.V. PUZYREVA¹, S.V. SITNIKOVA², M.V. BALABOKHINA³, D.T. YUSUPOVA²

 ¹Omsk State Medical University, Omsk

²Tuberculosis Infectious Disease Clinical Hospital No. 4, Omsk

³AIDS and Infectious Diseases Prevention and Control Center, Omsk

Contact details:

Puzyreva L.V. — MD, Associate Professor of the Higher Attestation Commission, Head of the Department of Pediatric Infectious Diseases

Address: 2 Lenin St., 644099 Omsk, Russian Federation, tel.: +7-913-149-1232, e-mail: puzirevalv@mail.ru

 With the increase in life expectancy of patients with HIV infection, concomitant pathology increases.

The purpose was to assess the multimorbidity of infectious pathology and the likelihood of a fatal outcome in patients of the tuberculosis dispensary.

Material and methods. We analyzed medical records of 107 fatal outcome in patients treated in the tuberculosis dispensary in 2024. The study is continuous, retrospective, descriptive, exploratory. We calculated the integral indicator of the condition severity. Licensed Statistica 13 software was used.

Results. In patients with HIV infection, the most common were opportunistic infections of herpes etiology. Death occurred with brain damage by cytomegalovirus and Epstein-Barr virus. Viral hepatitis B and C were recorded in 79% of cases, while cirrhosis as the outcome of the disease was noted in 35.5% of patients. Fungal diseases of the skin, nails and mucous membranes were found in half of the patients, and community-acquired bacterial pneumonia — in 45%. Tuberculosis was detected and confirmed in 88.1% of patients with HIV infection. Thus, the fatal outcome with the active course of multiple infections (of bacterial, viral, and fungal nature) occurred in 11.8%, most often with the progression of generalized tuberculosis lesions in combination with fungal, viral and bacterial infections — in 67.1% of cases. When calculating the integral indicator of the condition severity against the background of multimorbid pathology in patients with HIV infection, explainable correct data were obtained that definitely confirmed the fatal outcome.

Conclusion. At present, a person with HIV infection is a patient with a combined viral, combined bacterial and fungal infection. This must be taken into account when choosing treatment tactics. The integral indicator has proven its effectiveness in practice.

Key words: HIV infection, multimorbidity, cytomegalovirus, Epstein-Barr virus, tuberculosis.

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