N.A. POZDEEVA¹,4, A.N. TRUNOV²,³, O.M. GORBENKO³, A.P. SHVAYUK³, L.N. DOMENTEVA¹, I.A. FROLYCHEV¹, I.V. KULIKOV4

1 Cheboksary Branch of Federal State Budgetary Institution «Interbranch scientific and technical complex «Eyes microsurgery» named after acad. S.N. Fedorov» of the Ministry of Health of the Russian Federation, 10 Traktorostroiteley Ave., Cheboksary, Russian Federation 428028

2 Novosibirsk Branch of Federal State Budgetary Institution «Interbranch scientific and technical complex «Eyes microsurgery» named after acad. S.N. Fedorov» of the Ministry of Health of the Russian Federation, 10 Kolkhidskaya St., Novosibirsk, Russian Federation 630071

3 Federal State Budgetary Institution «Scientific Center of Clinical and Experimental Medicine of Siberian Branch of Russian Academy of Medical Sciences», 2 Timakova St., Novosibirsk, Russian Federation 630117

4 AI of Chuvashia «Postgraduate Doctors’ Training Institute» of the Ministry of Health and Social Development of Chuvash Republic, 3 Krasnaya sq., Cheboksary, Russian Federation 428032

Pozdeeva N.A. — Candidate of Medical Science, Deputy Director for Science of Cheboksary Branch of Federal State Budgetary Institution «Interbranch scientific and technical complex «Eyes microsurgery» named after acad. S.N. Fedorov» of the Ministry of Health of the Russian Federation, Associate Professor of Ophthalmology Course in AI of Chuvashia «Postgraduate Doctors’ Training Institute» of the Ministry of Health and Social Development of Chuvash Republic, tel. (8352) 30-50-81, e-mail: npozdeeva@mail.ru1,4

Trunov A.N. — D. med. Sc., Professor, Deputy Director for Science of Novosibirsk Branch of Federal State Budgetary Institution «Interbranch scientific and technical complex «Eyes microsurgery» named after acad. S.N. Fedorov» of the Ministry of Health of the Russian Federation, Head of the Laboratory of Immunology in Federal State Budgetary Institution «Scientific Center of Clinical and Experimental Medicine of Siberian Branch of Russian Academy of Medical Sciences», tel. +7-913-910-03-16, e-mail: trunov1963@yandex.ru2,3

Gorbenko O.M. — Cand. Sc. {Biology}, senior research associate, 2 Timakova St., Novosibirsk, Russian Federation 630117, tel. (383) 216-549-99, e-mail: trunov1963@yandex.ru3

Shvayuk A.P. — Cand. Sc. {Biology}, senior research associate, 2 Timakova St., Novosibirsk, Russian Federation 630117, tel. (383) 216-549-99, e-mail: trunov1963@yandex.ru3

Domenteva L.N. — Head of clinical laboratory, tel. (8352) 30-50-81, e-mail: npozdeeva@mail.ru1

Frolychev I. A. — junior research associate, tel. (8352) 30-50-81, e-mail: npozdeeva@mail.ru1

Kulikov I.V. — resident doctor of ophtalmology course, tel. (8352) 30-50-81, e-mail: npozdeeva@mail.ru4

An activity analysis of local inflammatory response to the implantation of artificial irido-lenticular diaphragm (ILD) in pre- and postoperative periods in patients with congenital and posttraumatic aniridia was performed basing on the content of cytokines IL-1β and IL-4 in tears, as well as on the assessment of the permeability degree of the blood-aqueous barrier according to the findings of laser tindalemetry. A significant increase of IL-1β concentration (more than 5.5 times) and IL-4 concentration (3.2 times more) in the early postoperative period was revealed, the return of IL-1β in the tear fluid to the values of the standard ratios in a month after operation on the background of an increased concentration of IL-4 4 in the course of the year was also found. The penetrance of the blood-aqueous barrier according to the findings of laser tindalemetry remains impaired for 6-12 months after the surgery.

Key words: artificial irido-lenticular diaphragm (ILD), interleukins IL-1β and IL-4, laser tindalemetry.

 

 

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