Z.A. GONCHAROVA, V.A. MEGERYAN

Rostov State Medical University, 29 Nakhichevanskiy pereulok, Rostov-on-Don, Russian Federation, 344022

Goncharova Z.A. — D. Med. Sc., Associate Professor of Nervous Diseases and Neurosurgery Department, tel.: (863) 263-12-40, +7-928-100-3-444; e-mail: centrms@mail.ru

Megeryan V.A. — postgraduate student of Nervous Diseases and Neurosurgery Department, tel.: +7-961-270-89-52,e-mail:udav110@mail.ru

Glucocorticosteroid (GCS) use is one of the most common causes of aseptic necrosis of femoral head (ANFH). The article presents the data of world literature on epidemiology, etiology, pathogenesis, clinical features, diagnostic and treatment of this pathology. 2 cases of ANFH development in patients with multiple sclerosis are presented, treated with oral GCS during one month, while pulse therapy with GCS, which had been repeatedly performed with these patients, did not lead to such complications. The most common risk factors for ANFH development observed in our patients were the prolonged use of methylprednisolone and cushingoid appearance.

Key words: multiple sclerosis, aseptic necrosis of femoral head, glucocorticoids.

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