A.KH. DAUSHEVA^1, 2, E.G. ZARUBINA¹, YU.V. BOGDANOVA²

 ¹Reaviz Medical University, Samara

²Samara Regional Clinical Hospital named after V.D. Seredavin, Samara

  Contact details:

Dausheva A.Kh. — PhD (Medicien), Associate Professor of the Department of Internal Diseases

Address: 227 Chapaevskaya St., Samara, Russian Federation, 443001, tel.: +7-917-109-03-43, e-mail: daushevaah@mail.ru

The purpose — to analyze the prevalence of polymorphism of the ACE Alu I/D angiotensin-converting enzyme gene (rs4646994) in patients with chronic obstructive pulmonary disease.

Material and methods. The study included 285 patients with COPD hospitalized at the regional pulmonological center of the Samara Regional Clinical Hospital named after V.D. Seredavin. Practically healthy individuals without hereditary predisposition and clinical manifestations of cardiorespiratory pathology were selected for control. The PCR method with allele-specific primers was used on SNP-express systems of NPO Litech.

Results. In the group of patients with a verified diagnosis of COPD, the pathological homozygous deletion D/D genotype significantly prevailed (χ² = 16.51, df = 2, p = 0.0001). The genetic cardiovascular risk in COPD patients associated with the deletion variant of the D/D ACE gene in our study was OR 8.87, 95% CI 2.61–30.13.

Conclusion. A personalized diagnostic approach allows identifying predictors of cardiovascular risk in COPD. The dominant role of cardiovascular mechanisms of comorbidity in COPD may be associated with the participation of some candidate genes of the renin-angiotensin-aldosterone system, in particular, insertion-deletion polymorphism rs4646994 of the angiotensin-converting enzyme gene.

Key words: chronic obstructive pulmonary disease, angiotensin-converting enzyme, gene polymorphism.

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