E.R. KADYSEVA^1, 2, L.YU. KULAGINA^1, 3, V.N. KHAZIAKHMETOVA²

 ¹Republic Clinical Hospital, Kazan

²Kazan Federal University, Kazan

³Kazan State Medical Academy — Branch Campus of the FSBEIFPE RMACPE MOH Russia, Kazan

 Contact details:

Kadyseva E.R. — clinical pharmacologist, researcher of the Research Department, postgraduate student of the Department of Fundamental Basis of Clinical Medicine

Address: 138 Orenburgskiy trakt, Kazan, Russian Federation, 420064, tel.: +7-987-261-39-93, e-mail: Elvina_Ganeeva@mail.ru

 The article presents the results of the study of safety of oral anticoagulants (OACs) use in trauma patients.Venous thromboembolic complications (VTEC) after surgery are among the most common indications for prescribing direct oral anticoagulants (OACs) in elderly patients, the treatment of which can cause serious problems and is associated with age-related characteristics of the organism.

The purpose — to study the safety of using oral anticoagulants (OACs) use in a trauma hospital.

Material and methods. A retrospective analysis was performed of 120 medical records of inpatients receiving oral anticoagulants to prevent blood clots after reconstructive surgery for bone fractures.In the study, 2 groups were considered: group 1 (without violations of hemostasis) — 50 people, aged 54.6 ± 18.0, group 2 (with impaired hemostasis) — 70 people, aged 61.3 ± 21.5.

Conclusions. There is a cause-and-effect relationship between a violation of hemostasis indicators (mainly an increase in APTT) and risk factors.

Key words: oral anticoagulants, safety and efficacy, polypharmacy, comorbid patient.

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