M.R. MIKITYUK^1,2, O.O. KHIZHNYAK¹, Yu.I. KARACHENTSEV^1,2

¹V.Ya. Danilevsky Institute ofEndocrine Pathology Problems of NAMS of Ukraine, 10 Artema Str., Kharkiv, the Ukraine61002

²Kharkiv Medical Academy of Postgraduate Education, 58 Korchagintsev St., Kharkiv, the Ukraine 61176

Mikityuk M.R. — Candidate of Medical Science, leading research associate at the Department of Age Endocrinology, assistant professor at the department of endocrinology and pediatric endocrinology of Kharkiv Medical Academy of Postgraduate Education, tel. + 38057-315-20-25, e-mail: myroslavamk@mail.ru^1,2

Khizhnyak O.O. — D. med. Sc., Professor, Head of Clinical Department, tel. (096) 579-82-50, e-mail: zenrost@mail.ru¹

Karachentsev Yu.I. — D. med. Sc., Professor, Head of V.Ya. Danilevsky Institute of Endocrine Pathology Problems, tel. (057) 315-11-88, e-mail: nauka@ipep.com.ua^1,2

The article gives the results of the analysis of age and sexcharacteristics of manifestation and clinical course of acromegaly in 123 patients. The analysis of possible reasons for late diagnosis of acromegaly in 86% of patients was performed. The necessity of age and sexcharacteristics of manifestation and clinical course of acromegaly for developing an individual strategy for diagnosis and treatment is proved.

Keywords: acromegaly, pituitary adenoma, somatotropinoma, mammosomatotropinoma, growth hormone.

REFERENCES

1. Ahmed S., Elsheikh M., Stratton I.M., Page R.C.L., Adams C.B.T., Wass J.A.H. Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience. Clinical Endocrinology, 1999, vol. 50, no. 5, pp. 561-567. DOI: 10.1046/j.1365-2265.1999.00760.x.

2. Cazabat L., Libe R., Perlemoine K., Rene-Corail F., Burnichon N., Gimenez-Roqueplo A.-P., et al. Germline inactivating mutations of the aryl hydrocarbon receptor-interacting protein gene in a large cohort of sporadic acromegaly: Mutations arefound in a subset of young patients with macroadenomas. European Journal of Endocrinology, 2007, vol. 157, no. 1, pp. 1-8. DOI:10.1530/EJE-07-0181.

3. Ben-Shlomo A., Melmed S. Acromegaly. Endocrinology and Metabolism Clinics of North America, 2008, vol. 37, no. 1, pp. 101-122. DOI:10.1016/j.ecl.2007.10.002.

4. Holdaway I.M., Rajasoorya C. Epidemiology of acromegaly.Pituitary, 1999, vol. 2, no. 1, pp. 29-41.

5. Giustina A., Barkan A., Casanueva F., et al. Criteriaforcureofacromegaly: Aconsensusstatement. Clinics in Endocrinology and Metabolism, 2000, vol. 85, no. 2, pp. 526-529.

6. Melmed S., Casanueva F.F., Hoffman A.R., Kleinberg D.L., Montori V.M., Schlechte J.A., Wass J.A.H. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 2011, vol. 96, no. 2, pp. 273-288. DOI:10.1210/jc.2010-1692.

7. Di Chiro G., Nelson K.B. The volume of the cella turcica. American Journal of Radiology, 1962, vol. 87, pp. 989-1008.

8. ProninV.S., AgadzhanyanS.E., Gitel’ E.P., MolitvoslovovaN.N., MarovaE.I., AlekseevaT.M., AntsiferovM.B. The clinical features of acromegaly and its treatment policy according to age at the onset of disease]. Problemyendokrinologii, 2006, vol. 52, no. 3, pp. 33-40. (in Russ.).

9. Molitvoslovova N.N. Akromegaliya: osobennosti klinicheskoy kartiny, oslozhneniy, effektivnost’ razlichnykh metodov lecheniya. Dokt. med. nauk. diss. Avtoref. [Acromegaly: Particularities of clinical picture, complications, the effectiveness of various treatment methods. Dr. med. sci. diss. Synopsis]. Moscow, 2011. 48 p.

10. Bex M., Abs R., T’Sjoen G., Mockel J., Velkeniers B., Muermans K., Maiter D. AcroBel – the Belgian registry on acromegaly: A survey of the ‘real-life’ outcome in 418 acromegalic subjects. European Journal of Endocrinology, 2007, vol. 157, no. 4, pp. 399-409. DOI:10.1530/EJE-07-0358.

11. Sargin, H., Gozu, H., Bircan, R., Sargin, M., Avsar, M., Ekinci, G., Yayla, A. A case of McCune-Albright syndrome associated with Gs alpha mutation in the bone tissue. Endocrine Journal, 2006, vol. 53, no. 1, pp. 35-44. DOI:10.1507/endocrj.53.35.

12. Tamura Y., Ishibashi S., Gotoda T., Yasufuku-Takano J., Takano K., et al. A kindred of familial acromegaly without evidence for linkage to MEN-I locus. Endocrine Journal, 2002, vol. 49, no. 4, pp. 425-431. DOI:10.1507/endocrj.49.425.

13. Mestron A., Webb S.M., Astorga R., Benito P., Catala M., Gaztambide S. Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA). European Journal of Endocrinology, 2004, vol. 151, no. 4, pp. 439-446. DOI:10.1530/eje.0.1510439.

14. Nabarro J.D.N. Acromegaly.Clinical Endocrinology, 1987, vol. 26, no. 4, pp. 481-512.