Advanced features of elastographic research methods on the example of their complex use
T.G. MOROZOVA1, A.V. BORSUKOV1
Smolensk State Medical University, 28 Krupskaya Str., Smolensk, Russian Federation, 214019
Morozova T.G. ― Cand. Med. Sc., Senior Researcher of the Scientific Research Laboratory «Diagnostic Researches and Low-invasive Technologies», tel. +7-910-767-45-60, е-mail: t.g.morozova@yandex.ru
Borsukov A.V. ― D. Med. Sc., Professor of the Department of Faculty Therapy, Head of the Scientific Research Laboratory «Diagnostic Researches and Low-invasive Technologies», tel. (4812) 63-22-10, e-mail: bor55@yandex.ru
The evaluation of clinical-diagnostic possibilities and prospects of elastographic research methods (transient, compression elastography and shear-wave elastography, compression elastography at endosnography) was made in 239 patients with diffuse liver diseases: steatohepatitis (n=66), hepatitis (n=98) and cirrhosis (n=75). Transient elastography of the liver and shear wave elastography are informative for all clinical forms of diffuse liver diseases; compression liver elastography is less informative for patients with cirrhosis; compression liver elastography at endosonography can be used if the patient has other indications for its use: pancreatitis, focuses in hepatopancreatoduodenal zone, choledocholithiasis, etc. The specificity of the prediction of elastographic comprehensive survey, with different combinations was 97.8%, forecast sensitivity ― 91.5%, prediction accuracy ― 94.3%. AUC was 0.931 with a 95% confidence interval [0.842-0.967].
Key words: complex liver elastography, diffuse liver diseases, pancreas.
REFERENCES
- Borsukov A.V., Kryukovskiy S.B., Pokusaeva V.N. et al. Elastografiya v klinicheskoy gepatologii (chastnye voprosy) [Elastography in clinical hepatology (private questions)]. Smolensk: Smolenskaya gorodskaya tipografiya, 2011. 276 p.
- Nechipay A.M., Orlov S.Yu., Fedorov E.D. EUSbuka: Rukovodstvo po endoskopicheskoy ul’trasonografii [Eusbook: Guide to endoscopic ultrasonography]. Moscow: Prakticheskaya meditsina, 2013. 400 p.
- Klyaritskaya I.L. Transient Elastography in the Evaluation of Liver Fibrosis. Krymskiy terapevticheskiy zhurnal, 2015, no. 3, pp. 18-30 (in Russ.).
- Tukhbatullin M.G., Akunova G.R., Galeevpa Z.M. Possibilities of echography in the diagnosis of liver cirrhosis and portal hypertension. Prakticheskaya meditsina. Sovremennye voprosy diagnostiki, 2014, no. 3 (79), pp. 54-61 (in Russ.).
- Morozova T.G., Borsukov A.V. Elastography in the endosonography of organs of the hepatopancreatoduodenal zone: a new direction of diagnosis. Uchenye zapiski Orlovskogo gosudarstvennogo universiteta, 2014, no. 3 (59), pp. 239-243 (in Russ.).
- Morozova T.G., Borsukov A.V. Diagnostic value of complex elastography in diffuse liver diseases: perspectives and possibilities. Doktor.Ru. (gastoroenterologiya), 2016, no. 1 (118), pp. 33-37 (in Russ.).
- Dynnik O.B., Linskaya A.V., Kobylyak N.N. Shift wave elastography and elastometry of liver parenchyma (methodical aspects). Promeneva diagnostika, promeneva terapiya, 2014, no. 1-2, pp. 73-82 (in Russ.).
- Bamber J., Cosgrove D., Dietrich C.F., et al. EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Part 1: Basic Principles and Technology. Ultraschall in Med, 2013, no. 34, pp. 169-184
- Cosgrove D., Bamber J., Dietrich C.F., et al. EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Part 2: Clinical Applications. DOI http://dx.doi.org/10.1055/s-0033-1335375 Published on-line: 2013.
- Friedrich-Rust M., Lupsor, M. de Knegt. Point Shear Wave Elastography by Acoustic Radiation Force Impulse Quantification in Comparison to Transient Elastography for the Noninvasive Assessment of Liver Fibrosis in Chronic Hepatitis C: A Prospective International Multicenter Study. Ultraschall in Med, 2015, no. 36, pp. 239-247.
- Huang Z., Zheng J., Zeng J., et al. Normal liver stiffness in healthy adults assessed by real-time Shear wave elastography and factors that infuence this method. Ultrasound Med. Biology, 2014, no. 40, pp. 2549-2555.
- Liao L.Y., Kuo K.L., Chiang H.S., et al. Acoustic radiation force impulse elastography of the liver in healthy patients: test location, reference range and infuence of gender and body mass index. Ultrasound Med. Biology, 2015, no. 41, pp. 698-704.