S.V. KHALIULLINA^1,2, A.V. ANOKHIN¹, Z.T. MUKHAMERDIEVA², E.S. PASHANINA²

¹Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

²Republican Clinical Infectious Diseases Hospital named after prof. A.Ph. Agaphonov, 83 Pobedy Ave., Kazan, Russian Federation, 420110

Khaliullina S.V. ― Cand. Med. Sc., Assistant of the Department of children’s infections, Infectious Disease Physician, tel. +7-917-860-92-46, e-mail: svekhal@mail.ru

Anokhin V.A. ― D. Med. Sc., Professor, Head of the Department of children’s infections, tel. (843) 267-81-00, e-mail: anokhin56@mail.ru

Mukhamerdieva Z.T. ― head of organizational and methodical cabinet, tel. +7-917-280-80-85, e-mail: muhamerdi@mail.ru

Pashanina E.S. ― Infectious Disease Physician, tel. +7-904-669-01-69, e-mail: medkati@mail.ru

This article deals with etiological structure of acute infectious diarrhea in children of the Republic of Tatarstan. It is shown that the leading position in the structure of modern acute intestinal infections is occupied by enteropathogenic viruses, mostly rotaviruses, in particular. Bacterial infections are recorded in 3.1-9.3% of the patients and salmonellosis predominates in this group. The article also proposes clinical criteria for selecting patients for screening for enteropathogenic bacterial flora: signs of hemorrhagic colitis, the frequency of episodes of loose stool is over 5 times per day, moderate vomiting — up to 2 times per day, high febrile fever (>39⁰C). Dedicated «anxiety symptoms» will increase the sensitivity of the bacteriological diagnosis method and optimize the approaches to the medical treatment of children suffering from acute intestinal infections.

Key words: acute intestinal infections, etiology, diagnostics, children.

REFERENCES

1. Gorelov A.V., Grigorovich M.S. Ostrye kishechnye infektsii u detey: otdalennye iskhody, faktory ikh opredelyayushchie. Optimizatsiya putey reabilitatsii [Acute intestinal infections in children: long-term outcomes, the factors determining them. Optimization of Rehabilitation ways]. Moscow-Kirov: Izd-vo OOO “Vesi”, 2012. 206 p.
2. Samsonov A.A., Plotnikova E.Yu., Borshch M.V. Post-infectious irritable bowel syndrome — a special form of functional bowel disease. Lechashchiy vrach, 2012, no. 7 (in Russ.), available at: http://www.lvrach.ru/2012/07/15435466/
3. Bekhtereva M.K., Anokhin V.A., Khaliullina S.V. Klinicheskie rekomendatsii (Protokol lecheniya) okazaniya meditsinskoy pomoshchi detyam, bol’nym kampilobakteriozom [Clinical guidelines (treatment protocol) care for children suffering from campylobacteriosis], 2010, available at: http://niidi.ru/specialist/regulations/
4. Sanitarno-epidemiologicheskie pravila “Profilaktika ostrykh kishechnykh infektsiy”: SP 3.1.1.3108-13 ot 09.10.2013 [Sanitary regulations «Prevention of acute intestinal infections»], available at: http://36.rospotrebnadzor.ru/documents/san_nor/ 14513/print_page/
5. Lobzin Yu.V., Yakushin S.B., Zakharenko S.M. Practical recommendations for the management of patients with infectious diarrhea. Guidelines for clinicians. According to the materials of the recommendations of the American Society of Infectious Diseases. KMAKh, 2001, vol. 3, no. 2, pp. 163-182 (in Russ.).
6. Yuhas Y. et al. Involvement of tumor necrosis factor alpha and interleukin-1beta in enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae. Infect. Immun, 1999, vol. 67 (3), pp. 1455-1460.
7. Farthing M. et al. Acute diarrhea in adults and children: a global perspective. World Gastroenterology Organisation Global Guidelines, 2012, available at: http://www.worldgastroenterology.org/assets/export/userfiles/AcuteDiarrhea_long_FINAL_120604.pdf
8. Guarino A. et al. ESPGHAN/ESPID Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe. Update 2014. J. Pediatr. Gastroenterol. Nutr, 2014, vol. 59 (1), pp. 132-152.
9. Khaliullina S.V. Sovremennye printsipy diagnostiki i lecheniya ostrykh kishechnykh infektsiy u detey: avtoref. … d-ra med. nauk [Modern principles of diagnosis and treatment of acute intestinal infections in children. Synopsis of dis. Dr med. sciences]. Kazan, 2016. 40 p.
10. Wiegering V. et al. Gastroenteritis in childhood: a retrospective study of 650 hospitalized pediatric patients. International Journal of Infectious Diseases, 2011, vol. 15, pp. 401-407.
11. Il’ina N.O. Klinicheskaya otsenka sovremennykh metodov diagnostiki ostrykh kishechnykh infektsiy u detey: avtoref. dis. … kand. med. nauk [Clinical evaluation of modern methods of diagnostics of acute intestinal infections in children. Synopsis of dis. PhD med. sciences]. Moscow, 2006. 21 p.