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  •  Acute coronary syndrome in rheumatoid arthritis

    Редактор | 2019, Literature reviews, Practical medicine part 17 №2. 2019 | 5 апреля, 2019

    N.A. TSIBULKIN1, A.I. ABDRAHMANOVA2, I.V. ABDULYANOV1, E.A. ACTSL1

    1Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan

    2Kazan (Volga Region) Federal University, Kazan

     Contact details:

    Tsibulkin N.A. ― PhD (medicine), Department of Cardiology, Roentgenendovascular and Cardiovascular Surgery

    Address: 36 Butlerov Str., Kazan, Russian Federation, 420012, tel. (843) 261-74-11, e-mail: kldkgma@mail.ru

     Objective ― to review and analyze the modern scientific publications on the features of acute forms of coronary heart disease in patients with rheumatoid arthritis.

    Material and methods. The review of the main publications in modern periodic scientific literature on the subject of characteristic features of development and clinical course of acute coronary syndrome and myocardial infarction in patients with concurrent rheumatoid arthritis. 

    Results. The increased risk of development of atherosclerosis is connected with chronic systemic inflammation. The rheumatoid arthritis is a chronic systemic disease, and its existence causes high risk of development of atherosclerosis and its complications. This is manifested in higher frequency of cerebral and cardiovascular events in such patients compared to the general population. The cardiovascular complications are the main cause of high mortality in rheumatoid arthritis patients.

    Conclusion. The more severe course of myocardial infarction and increased in-hospital lethality is characteristic of patients with rheumatoid arthritis. The increased level of recurrence of acute coronary syndrome and related lethality remains in such patients for a long time after myocardial infarction.

    Key words: rheumatoid arthritis, atherosclerosis, acute coronary syndrome.

    REFERENCES

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    2. Nielsen N., Frisch M., Rostgaard K., et al. Autoimmune diseases in patients with multiple sclerosis and their first-degree relatives: A nationwide cohort study in Denmark. Mult Scler, 2008, no. 14, pp. 823-829.
    3. Lozano Rivas N., Pastor-Pérez F.J., Flores-Blanco P.J., et al. Impact of Autoimmune Disease on the Management and Prognosis of Acute Coronary Syndrome. Rev. Esp. Cardiol. (Engl Ed), 2017, no. 70 (12), pp. 1145-1147.
    4. Sugimoto N., Nakajima A., Inoue E., et al. Incidence of comprehensive hospitalization due to infection, cardiovascular disease, fractures, and malignancies in patients with rheumatoid arthritis. Rheumatol Int., 2017, no. 37 (11), pp. 1871-1878.
    5. Ben-Zvi I., Goldenberg I., Matetzky S., et al. The impact of inflammatory rheumatic diseases on the presentation, severity, and outcome of acute coronary syndrome. Clin. Rheumatol., 2016, no. 35, pp. 233-237.
    6. Mantel A., Holmqvist M., Jernberg T., et al. Rheumatoid arthritis is associated with a more severe presentation of acute coronary syndrome and worse short-term outcome. Eur. Heart J., ― 2015, no. 36 (48), pp. 3413-3422.
    7. Mantel A., Holmqvist M., Jernberg T., et al. Long-term outcomes and secondary prevention after acute coronary events in patients with rheumatoid arthritis. Ann. Rheum. Dis, 2017, no. 76 (12), pp. 2017-2024.
    8. Holmqvist M., Ljung L., Askling J. Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks. Ann. Rheum. Dis, 2017, no. 76 (10), pp. 1642-1647.
    9. Blankenberg S., Rupprecht H.J., Poirier O., et al. Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation, 2003, no. 107, pp. 1579-1585.
    10. Montecucco F., Mach F. Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis. Rheumatology (Oxford), 2009, no. 48, pp. 11-22.
    11. Dixon W.G., Watson K.D., Lunt M., et al. Reduction in the incidence of myocardial infarction in patients with rheumatoid arthritis who respond to anti-tumor necrosis factor alpha therapy: results from the British Society for Rheumatology Biologics Register. Arthritis Rheum, 2007, no. 56, pp. 2905-2912.
    12. Gonzalez-Gay M.A., Gonzalez-Juanatey C., Vazquez-Rodriguez T.R., et al. Insulin resistance in rheumatoid arthritis: the impact of the anti-TNF-alpha therapy. Ann. N Y Acad. Sci., 2010, no. 1193, pp. 153-159.
    13. Wong M., Oakley S.P., Young L., et al. Infliximab improves vascular stiffness in patients with rheumatoid arthritis. Ann. Rheum. Dis, 2009, no. 68, pp. 1277-1284.
    14. Huang C.Y., Lin T.T., Yang Y.H., et al. Effect of statin therapy on the prevention of new-onset acute coronary syndrome in patients with rheumatoid arthritis. Int. J. Cardiol, 2018, no. 15 (253), pp. 1-6.

    Метки: 2019, A.I. ABDRAHMANOVA, acute coronary syndrome, atherosclerosis, E.A. ACTSL, I.V. ABDULYANOV, N.А. TSIBULKIN, Practical medicine part 17 №2. 2019, rheumatoid arthritis

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