A.A. NIGMATIYANOVA¹, L.I. FEISKHANOVA¹, R.Z. ABDRAKIPOV², R.M. KHASANOV^1,2

¹Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

²Republican Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064 

Nigmatiyanova A.A. ― postgraduate student of the Department of Hospital Therapy, tel. +7-987-277-60-39, e-mail: anzilya-s@yandex.ru

Feiskhanova L.I. ― Cand. Med. Sc., Associate Professor of the Department of Hospital Therapy, tel. +7-917-275-21-66, e-mail: ljuts@rambler.ru

Abdrakipov R.Z. ― Head of the Rheumatology Department, tel. (843) 231-21-67, e-mail: anzilya-s@yandex.ru

Khasanov R.M. ― Cand. Med. Sc., Associate Professor of the Department of Surgery Diseases №1, Head of the Department of Thoracic Surgery, tel. (843) 231-21-79, e-mail: khasanov1949@mail.ru 

The article presents a clinical case of a combination of various clinical manifestations of ankylosing spondylitis which led to the chest rigidity and decreased bronchial patency with severe lesions of the lungs and pleura. Thrombocytosis and anemia are consequences of the systemic disease of the connective tissue. One should beware the probable varied comorbid pathology which can surpass the ankylosing spondylitis in severity.

Key words: ankylosing spondylitis, pulmonary-pleural involvement, anemia, thrombocytosis.

REFERENCES

1. Federal’nye klinicheskie rekomendatsii po diagnostike i lecheniyu ankiloziruyushchego spondilita, utverzhdennye Assotsiatsiey revmatologov Rossii v 2013 godu s dopolneniyami ot 2016 goda [Federal guidelines for the diagnosis and treatment of ankylosing spondylitis, approved by the Russian Association of Rheumatology in 2013, with additions by 2016.].
2. L. Beth Gadkowski, Janson E. Stout. Cavitary pulmonary disease. Clinical Microbiology Reviews, April, 2008, 29 (3), pp. 305-333.
3. Naveen Kanathur, Teofilo Lee-Chiong Pulmonary manifestations of ankylosing spondylitis. Clinics in chest medicine, September, 2010, 31 (3), pp. 547-554.
4. Ki-Jo Kim, Chul-Soo-Cho Anemia of chronic disease in ankylosing spondylitis: improvement following anti-TNF therapy. Archives of rheumatology, 2012, 27 (2), pp. 90-97.
5. Laura Niccoli, Carlotta Nannini, Emanuele Cassara et al. Frequensy of anemia of inflammation in patients with ankylosing spondylitis requiring anti-TNF α drugs and therapy-induced changes. International journal of rheumatic diseases, February, 2012, 15 (1), pp. 56-61.
6. Valentini G., Chianese U., Tirri G., Giordano M. Trombocytosis in progressive generalized sclerosis (scleroderma) and in other rheumatic diseases. Z. Rheumatology, Jul-Aug, 1978, 37 (7-8), pp. 233-241.